Deciphering the MLL induced oncogenic network

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MLL fusion proteins are transcriptional activators that act as unusually potent oncoproteins. The presence of a MLL fusion can fully transform myeloid cells without any or only with very few additional mutations. This implies that the gene-set, induced by MLL fusions, encodes the full complement of activities necessary for the generation of a clinically overt leukemia. Functional dropout screens have highlighted two transcriptional regulators, an ETS-type transcription factor and a potential chromatin acetylation modifier as critical within this gene regulatory network. Here we intend to investigate the functional importance of these two factors for the establishment of a transformation associated gene expression pattern.