Deciphering the MLL induced oncogenic network

破译 MLL 诱导的致癌网络

• 批准号: 395840986
• 负责人: Professor Dr. Robert Slany
• 金额: --
• 依托单位: Lehrstuhl für Genetik - AG Falk Nimmerjahn
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/395840986?language=en
• 关键词: Deciphering; MLL; induced; oncogenic; network

MLL fusion proteins are transcriptional activators that act as unusually potent oncoproteins. The presence of a MLL fusion can fully transform myeloid cells without any or only with very few additional mutations. This implies that the gene-set, induced by MLL fusions, encodes the full complement of activities necessary for the generation of a clinically overt leukemia. Functional dropout screens have highlighted two transcriptional regulators, an ETS-type transcription factor and a potential chromatin acetylation modifier as critical within this gene regulatory network. Here we intend to investigate the functional importance of these two factors for the establishment of a transformation associated gene expression pattern.

MLL 融合蛋白是转录激活剂，可作为异常有效的癌蛋白。 MLL 融合的存在可以完全转化骨髓细胞，无需任何或仅具有很少的额外突变。这意味着由 MLL 融合诱导的基因组编码了产生临床明显白血病所需的全部活性。功能性缺失筛选强调了两种转录调节因子、一种 ETS 型转录因子和一种潜在的染色质乙酰化修饰剂，在该基因调控网络中至关重要。在这里，我们打算研究这两个因素对于建立转化相关基因表达模式的功能重要性。