Functional analysis and application of glutathiolated plant products

我们研究了食源性小分子的Toll样受体(TLR)信号抑制潜能。在广泛筛选甘蓝类蔬菜提取物对TLR抑制活性的基础上，我们发现甘蓝是最丰富的来源，并鉴定出3-(甲基亚硫基)丙基异硫氰酸酯(Iberin)是甘蓝中主要的TLR抑制剂之一。我们还研究了伊贝林的谷胱甘肽和蛋白质反应性。

We have investigated the Toll-like receptor (TLR) signaling inhibitory potential of food-derived small molecules. Based on an extensive screening of Brassica vegetable extracts for the TLR-inhibitory activity, we found cabbage as the richest source and identified 3-(methylsulfinyl)propyl isothiocyanate (iberin), an analogue of sulforaphane isolated from broccoli, as one of the major TLR inhibitor in cabbage. We also studied glutathiolation and protein reactivity of iberin.