Fundamental study for the standardization of gastrointestinal endoscopy biopsies

胃肠内镜活检标准化基础研究

• 批准号: 24658264
• 负责人: NAKAYAMA Hiroyuki
• 金额: $ 2.66万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24658264/
• 关键词: 内視鏡; 炎症性胃腸疾患; リンパ腫; イヌ; ネコ; 病理診断; 消化管内視鏡; クローナリティ検査; 病理組織検査; TCR; IgH; セリアック病; 炎症性腸疾患; 低グレードリンパ腫; 病理組織診断; クローナリティー検査

The aim of the study is to standardize the pathologic diagnostic criteria of canine and feline inflammatory bowel disease (IBD) and low grade lymphoma, and to elucidate the pathogenesis of the diseases. In Veterinary medical center, the University of Tokyo, Japan animal referral Medical Center (JARMeC), and Japan small animal Medical Center (JSAMC), the biopsy samples of feline and canine protein losing enteropathy admitted conducted endoscope, were prepared and diagnosed with identical procedures and pathologists. The relationship between pathological diagnoses and clinical prognosis, gene clonality tests, T/NK cells distribution patterns, and the expression of various molecular markers were investigated, respectively. Present study provided the standardized indicators of endoscopic biopsy pathology diagnosis, and also revealed the close correlation between pathogenesis of IBD and low grade lymphoma.

本研究旨在规范犬、猫炎症性肠病（IBD）及低级别淋巴瘤的病理诊断标准，阐明其发病机制。在东京大学兽医医学中心、日本动物转诊医学中心（JARMeC）和日本小动物医学中心（JSAMC），采用相同的程序和病理学家对内镜下入院的猫和犬失蛋白肠病活检标本进行准备和诊断。分别观察病理诊断与临床预后的关系、基因克隆检测、T/NK细胞分布规律及各种分子标志物的表达。本研究提供了内镜活检病理诊断的标准化指标，也揭示了IBD的发病机制与低级别淋巴瘤的密切相关。

项目成果

Value of the 13C-Urea Breath Test for Detection of Gastric Helicobacter spp. Infection in Dogs Undergoing Endoscopic Examination

• DOI: 10.1292/jvms.12-0528
• 发表时间: 2013-08-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Kubota, Sanae;Ohno, Koichi;Tsujimoto, Hajime
• 通讯作者: Tsujimoto, Hajime

Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory bowel disease and their possible role in recruitment of intraepithelial lymphocytes

• DOI: 10.1016/j.vetimm.2012.04.021
• 发表时间: 2012-08-15
• 期刊: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
• 影响因子: 1.8
• 作者: Maeda, Shingo;Ohno, Koichi;Tsujimoto, Hajime
• 通讯作者: Tsujimoto, Hajime

消化管内視鏡生検における炎症およびリンパ腫の病理組織診断とクローナリティ検査の相関

胃肠道内镜活检炎症和淋巴瘤组织病理学诊断与克隆性检测的相关性

• 发表时间: 2013
• 作者: 二瓶和美;吉田桂子;内田和幸;小川博之
• 通讯作者: 小川博之

Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease

• DOI: 10.1016/j.tvjl.2012.02.026
• 发表时间: 2012-10-01
• 期刊: VETERINARY JOURNAL
• 影响因子: 2.2
• 作者: Maeda, Shingo;Ohno, Koichi;Tsujimoto, Hajime
• 通讯作者: Tsujimoto, Hajime