Regulation of mammalian neuronal system by a novel microRNA "mirtron".

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In this study, we revealed using knockout mice that mir-877, a mammalian-specific mirtron, regulated the functions of serotonergic neurons through suppression of gene X which is involved in serotonergic and adrenergic neural development, and also regulated the serum glucocorticoid level, which is a mediator of stress responces, through suppression of gene Y. Our findings suggested that mammalian-specific mirtrons could regulate varieties of central nervous functions.