Regulation of mammalian neuronal system by a novel microRNA "mirtron".

通过新型 microRNA“mirtron”调节哺乳动物神经系统。

• 批准号: 24659033
• 负责人: MIZUGUCHI Hiroyuki
• 金额: $ 2.5万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659033/
• 关键词: microRNA; mirtron; セロトニン神経; ストレス; 交感神経; セロトニン

In this study, we revealed using knockout mice that mir-877, a mammalian-specific mirtron, regulated the functions of serotonergic neurons through suppression of gene X which is involved in serotonergic and adrenergic neural development, and also regulated the serum glucocorticoid level, which is a mediator of stress responces, through suppression of gene Y. Our findings suggested that mammalian-specific mirtrons could regulate varieties of central nervous functions.

在本研究中，我们利用基因敲除小鼠发现了哺乳动物特有的Mir-877通过抑制参与5-羟色胺和肾上腺素能神经发育的基因X来调节5-羟色胺能神经元的功能，并通过抑制基因Y来调节作为应激反应中介的血清糖皮质激素水平。我们的研究结果表明，哺乳动物特有的MIRT可以调节多种中枢神经功能。