The development of the novel targeted adenovirus vectors
The development of the novel targeted adenovirus vectors
批准号:
22390030
负责人:
MIZUGUCHI Hiroyuki
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
为了实现成功的基因治疗,需要将基因安全地递送到靶组织和细胞中并使基因稳定表达。本研究通过对腺病毒衣壳蛋白进行化学或基因工程改造,并在腺病毒载体中插入新的靶向分子,从而构建了新型的靶向腺病毒载体
英文摘要
To accomplish successful gene therapy,it is necessary to deliver the gene safely into targeted tissues and cells with the stable gene expression. We developed the novel targeted adenovirus (Ad) vectors using the strategies of the chemical or genetic engineering modification of Ad capsid protein and the insertion of the novel targeting molecules into Ad vector
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DOI:
10.1016/j.biomaterials.2010.10.060
发表时间:
2011-02
期刊:
Biomaterials
影响因子:
14
作者:
[Emi Suzuki-Kouyama;K. Katayama;F. Sakurai;Tomoko Yamaguchi;S. Kurachi;K. Kawabata;S. Nakagawa;H. Mizuguchi]
通讯作者:
Emi Suzuki-Kouyama;K. Katayama;F. Sakurai;Tomoko Yamaguchi;S. Kurachi;K. Kawabata;S. Nakagawa;H. Mizuguchi
Development of a Novel targeted Adenovirus Vector Displaying Monobody Binding to Anti-Vascular Endothelial Growth Factor Receptor 2 in a Fiber Protein.
开发一种新型靶向腺病毒载体,该载体显示与纤维蛋白中的抗血管内皮生长因子受体 2 结合的单体。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Matsui H, Sakurai F, Tachibana M, Kurachi S, Katayama K, Mizuguchi H]
通讯作者:
Mizuguchi H
増殖型アデノウイルスベクターより非特異的に発現するウイルス遺伝子の定量的発現解析
增殖腺病毒载体非特异性表达的病毒基因的定量表达分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[清水かほり, 他]
通讯作者:
他
DOI:
10.1021/mp200121z
发表时间:
2011-07-01
期刊:
MOLECULAR PHARMACEUTICS
影响因子:
4.9
作者:
[Shimizu, Kahori, Sakurai, Fuminori, Mizuguchi, Hiroyuki]
通讯作者:
Mizuguchi, Hiroyuki
DOI:
10.1021/mp300248u
发表时间:
2012-12-01
期刊:
MOLECULAR PHARMACEUTICS
影响因子:
4.9
作者:
[Bennett, David, Sakurai, Fuminori, Mizuguchi, Hiroyuki]
通讯作者:
Mizuguchi, Hiroyuki
共 37 条
Regulation of mammalian neuronal system by a novel microRNA "mirtron".
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批准号:24659033
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2012
-
负责人:MIZUGUCHI Hiroyuki
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依托单位:
Exploring natural resources-derived compounds that suppress up-regulation of histamine H1 receptor gene expression as a diseases-sensitive gene
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批准号:22580132
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2010
-
负责人:MIZUGUCHI Hiroyuki
-
依托单位:
Development of Self-Compacting concrete Using Whole Recycled Materials from Demolished Concrete Structure as Aggregate and Powder by High grade Recycling System
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批准号:17560408
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:MIZUGUCHI Hiroyuki
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依托单位:
Research of gene transfer into nonhuman promates using novel types of adenovirus vectors
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批准号:17390047
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.23万
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财政年份:2005
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负责人:MIZUGUCHI Hiroyuki
-
依托单位:
Development of Water Purification Systems using Porous Concrete with Little Maintenance
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批准号:12450179
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.25万
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财政年份:2000
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负责人:MIZUGUCHI Hiroyuki
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依托单位:
海外基金