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The development of the novel targeted adenovirus vectors

The development of the novel targeted adenovirus vectors
新型靶向腺病毒载体的研制
批准号:
22390030
负责人:
MIZUGUCHI Hiroyuki
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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项目成果

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中文摘要
翻译
为了成功地完成基因治疗,必须将基因安全地传递到目标组织和细胞中并稳定表达。我们利用化学或基因工程修饰Ad衣壳蛋白,并将新的靶向分子插入到Ad载体中,开发了新的靶向腺病毒(Ad)载体
英文摘要
To accomplish successful gene therapy,it is necessary to deliver the gene safely into targeted tissues and cells with the stable gene expression. We developed the novel targeted adenovirus (Ad) vectors using the strategies of the chemical or genetic engineering modification of Ad capsid protein and the insertion of the novel targeting molecules into Ad vector
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会议论文
DOI: 10.1016/j.biomaterials.2010.10.060
发表时间: 2011-02
期刊: Biomaterials
影响因子: 14
作者: [Emi Suzuki-Kouyama;K. Katayama;F. Sakurai;Tomoko Yamaguchi;S. Kurachi;K. Kawabata;S. Nakagawa;H. Mizuguchi]
通讯作者: Emi Suzuki-Kouyama;K. Katayama;F. Sakurai;Tomoko Yamaguchi;S. Kurachi;K. Kawabata;S. Nakagawa;H. Mizuguchi
Development of a Novel targeted Adenovirus Vector Displaying Monobody Binding to Anti-Vascular Endothelial Growth Factor Receptor 2 in a Fiber Protein.
开发一种新型靶向腺病毒载体,该载体显示与纤维蛋白中的抗血管内皮生长因子受体 2 结合的单体。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Matsui H, Sakurai F, Tachibana M, Kurachi S, Katayama K, Mizuguchi H]
通讯作者: Mizuguchi H
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [清水かほり, 他]
通讯作者:
DOI: 10.1021/mp200121z
发表时间: 2011-07-01
期刊: MOLECULAR PHARMACEUTICS
影响因子: 4.9
作者: [Shimizu, Kahori, Sakurai, Fuminori, Mizuguchi, Hiroyuki]
通讯作者: Mizuguchi, Hiroyuki
37
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    • 批准号:
      24659033
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2012
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    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2005
    • 负责人:
      MIZUGUCHI Hiroyuki
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