Identification of immunogenic nucleic acid-protein complex

免疫原性核酸-蛋白质复合物的鉴定

• 批准号: 24659177
• 负责人: NEGISHI Hideo
• 金额: $ 2.5万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659177/
• 关键词: 免疫性核酸; 炎症; RNA; 核酸

In my previous study, I isolated chemical compounds which bound to nucleic acid. Some of them had strong therapeutic effect on inflammatory diseases in the mice model. From this and other results, I hypothesized that the compounds targeted the endogenous immunogenic nucleic acid-protein complex. In this study, I tried to identify them and successfully identified both immunogenic nucleic acid and protein. Further study may provide the new strategy for the therapy of inflammatory diseases.

在我之前的研究中，我分离了与核酸结合的化合物。部分药物对小鼠模型炎症性疾病有较强的治疗作用。根据这一结果和其他结果，我假设这些化合物针对内源性免疫原性核酸-蛋白复合物。在这项研究中，我尝试对它们进行鉴定，并成功地鉴定了免疫原性核酸和蛋白质。进一步的研究可能为炎症性疾病的治疗提供新的策略。