A study on a novel therapeutic strategy for Alzheimer's disease Using neurosteroids.

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The aim of this study was to test whether the neurosteroids PREGS and DEHA improve the survival rate and function of newborn hippocampal granule cells in the dentate gyrus (DG), which are crucial for learning and memory, by using Alzheimer's disease (AD) model mice. Each mouse was given a daily subcutaneous injection of PREGS or DHEA at a dose of 20 mg/kg for a month, and morphological development of newborn granule cells in the DG was examined for 20 days from the day 20 after the first injection. Both agents largely improved the morphological development of new born cells, but only PREGS facilitated the synaptogenesis of newborn cells to preexisting neural circuits and contributed to the final survival rate of newborn granule cells. It is strongly suggested that PREGS can be a promising therapeutic drug for AD.