A study on the novel therapeutic drugs to protect delayed neuronal death after stroke

一旦发生卒中，除了危象后5小时内进行溶栓治疗外，几乎没有有效的治疗方法，但其应用比例不到5%。我们注意到脑卒中的严重后遗症大多是由缺血迟发性神经元死亡引起的，从危机发生后2天开始，我们致力于开发能够保护神经元免受缺血性损伤的治疗药物。通过对短暂性脑缺血动物模型的研究，我们发现某些神经类固醇在缺血后48-72小时内给予，可以在很大程度上抑制缺血性延迟性神经元死亡和学习/运动障碍。此外，我们揭示了神经类固醇神经保护作用的潜在分子机制。

Once a stroke happens, there is virtually no effective treatment except for thrombolysis within 5 hrs after the crisis, but its application ratio is less than 5%. We noticed that most of serious after effects of stroke are caused by the ischemic delayed neuron death starting from 2 days after the crisis, and aimed to develop therapeutic drugs that can protect neurons from ischemic damages. By using animal models with transient brain ischemia, we found that certain neurosteroids, when administered within 48-72 hrs after the crisis, could largely inhibit the ischemic delayed neuron death and learinig/motility impairment. Furthermore we revealed the underlying molecular mechanisms of the neuroprotective effects of the neurosteroids.