Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism
Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism
批准号:
21247021
负责人:
SOKABE Masahiro
金额:
$29.37万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The actin depolymerizing factor (ADF) cofilin was found to bind selectively to relaxed actin filaments and severed them, indicating that actin filaments work as a negative tension sensor through a tension dependent regulation of cofilin activity. It is supposed that increased torsional fluctuations of relaxed actin filaments accelerate the cofilin binding to them.
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DOI:
10.1113/jphysiol.2012.244145
发表时间:
2013-03-01
期刊:
JOURNAL OF PHYSIOLOGY-LONDON
影响因子:
5.5
作者:
[Grygorczyk, Ryszard, Furuya, Kishio, Sokabe, Masahiro]
通讯作者:
Sokabe, Masahiro
神経ステロイドによるアルツハイマー病の予防・治療の可能性
使用神经类固醇预防和治疗阿尔茨海默病的可能性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sokabe M, Furuya K, Sokabe M, Sokabe M, 曽我部正博, 曽我部正博, 曽我部正博, Sokabe M, Sokabe M, Sokabe M, Sokabe M, Sokabe M, Sokabe M, 曽我部正博]
通讯作者:
曽我部正博
The Impact of EmergingNano-Mechanobiology
新兴纳米力学生物学的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Sokabe M, Furuya K, Sokabe M, Sokabe M, 曽我部正博, 曽我部正博, 曽我部正博, Sokabe M, Sokabe M, Sokabe M, Sokabe M, Sokabe M, Sokabe M, 曽我部正博, Sokabe M]
通讯作者:
Sokabe M
細胞力覚の生物物理学と比較生理学、シンポジウム「メカノトランスダクションと生理機能」
细胞力感的生物物理学和比较生理学,研讨会“机械传导与生理学”
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Shuhei OKABE, Tsuyoshi HIRAJIMA, Moriyasu NONAKA, Satoshi KUMAGAI, et al., 曽我部正博]
通讯作者:
曽我部正博
The role of actin filaments as a force-transmitter and a force-sensor
肌动蛋白丝作为力传递器和力传感器的作用
DOI:
--
发表时间:
期刊:
In Recent Advances in Mechanobiology
影响因子:
--
作者:
[Tatsumi, H., K.Hayakawa, H.Hirata, and M.Sokabe]
通讯作者:
and M.Sokabe
共 49 条
A study on a novel therapeutic strategy for Alzheimer's disease Using neurosteroids.
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批准号:24659259
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:SOKABE Masahiro
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依托单位:
Possible roles of actomyosin and mechanosensitive channels in substrate rigidity sensing of cells
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批准号:24247028
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.96万
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财政年份:2012
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负责人:SOKABE Masahiro
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依托单位:
A study on the novel therapeutic drugs to protect delayed neuronal death after stroke
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批准号:22659109
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.96万
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财政年份:2010
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负责人:SOKABE Masahiro
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依托单位:
Creation of Mechanobiology Based on Mechanosensitive Channels
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批准号:16GS0308
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项目类别:Grant-in-Aid for Creative Scientific Research
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资助金额:$318.49万
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财政年份:2004
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负责人:SOKABE Masahiro
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依托单位:
Analyses of activation mechanisms of cell mechanosensor at nano- and microlevels.
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批准号:15086207
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$20.48万
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财政年份:2003
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负责人:SOKABE Masahiro
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依托单位:
STUDY ON THE STRUCTURE FUNCTION AND PHYSIOLOGICAL ROLES OF SA CHANNELS
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批准号:13480216
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2001
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负责人:SOKABE Masahiro
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依托单位:
CELL REMODELING BY MECHANICAL STIMULI : ROLE OF FOVAL ADHESION MOLECULES IN POLARITY FORMATION
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批准号:10480180
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:1998
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负责人:SOKABE Masahiro
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依托单位:
STUDY ON THE DEVELOPMENT OF MOLECULAR BIOLOGY AND PHYSIOLOGY OF SA CHANNELS
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批准号:09044283
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.37万
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财政年份:1997
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负责人:SOKABE Masahiro
-
依托单位:
STRETCH-INDUCED CELL MORPHOGENEISI : MOLECULAR MECHANISM OF DIRECTIONSENSITIVITY AND POLARITY FORMATION
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批准号:08458206
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.44万
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财政年份:1996
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负责人:SOKABE Masahiro
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依托单位:
Joint Study on the Molecular Biology of SA Channels
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批准号:07044245
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.5万
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财政年份:1995
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负责人:SOKABE Masahiro
-
依托单位:
MOLECULAR MECHANISM OF MORPHOLOGICAL RESPONSE TO MECHANICAL STIMULI IN ENDOTHELIAL CELLS
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批准号:06454665
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1994
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负责人:SOKABE Masahiro
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依托单位:
Joint Study on the Physiological Role of SA channel
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批准号:05044158
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$1.92万
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财政年份:1993
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负责人:SOKABE Masahiro
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依托单位:
PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS
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批准号:05304055
-
项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$11.26万
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财政年份:1993
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负责人:SOKABE Masahiro
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依托单位:
Biophysical and Molecularbiological Study on Stretch Channel
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批准号:03044073
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$2.43万
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财政年份:1991
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负责人:SOKABE Masahiro
-
依托单位:
Screening of SA-channel mutant in Drosophila
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批准号:03454558
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.42万
-
财政年份:1991
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负责人:SOKABE Masahiro
-
依托单位:
Quantitative Study of Stretch Channel Activation.
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批准号:01570044
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
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财政年份:1989
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负责人:SOKABE Masahiro
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依托单位:
Development of Ultra-high Power Video Microscope for Patch Clamp Study.
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批准号:01880028
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
-
资助金额:$6.21万
-
财政年份:1989
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负责人:SOKABE Masahiro
-
依托单位:
Reconstitution of phototransduction channel from frog rod outer segments in planar lipid bilayers
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批准号:62570041
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1987
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负责人:SOKABE Masahiro
-
依托单位:
海外基金