RB1CC1 and p62/SQSTM1 abnormalities in human carcinogenesis, and their utilities on clinical application

RB1CC1和p62/SQSTM1异常在人类致癌过程中的作用及其临床应用

• 批准号: 24659272
• 负责人: OKABE Hidetoshi
• 金额: $ 2.5万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659272/
• 关键词: 腫瘍検査; p62/SQSTM1; RB1CC1; Nrf2; GSH

Staining of p62/SQSTM1 and RB1CC1 was scored by using a tissue microarray of lung cancers. RB1CC1 is expressed only in the cytoplasm of lung cancers, suggesting poor prognosis of lung cancers. p62/SQSTM1 accumulation was further associated with the worse survival, especially the worst in the cases with both expressions of p62/SQSTM1 and RB1CC1. p62/SQSTM1 could become a biomarker of worse prognosis in lung cancer cases.In oral squamous cell carcinomas, p62/SQSTM1 contributed to induce glutathione in oral carcinoma cells, and to cause a resistance to radiation therapy. Clinico-pathological detection of p62/SQSTM1 accumulation could predict poor prognosis, and could be a new biomarker in the cases of oral squamous cell carcinoma.

使用肺癌组织微阵列对 p62/SQSTM1 和 RB1CC1 的染色进行评分。 RB1CC1仅在肺癌细胞质中表达，提示肺癌预后不良。 p62/SQSTM1 积累进一步与较差的生存率相关，尤其是在同时表达 p62/SQSTM1 和 RB1CC1 的病例中。 p62/SQSTM1可能成为肺癌病例预后较差的生物标志物。在口腔鳞状细胞癌中，p62/SQSTM1有助于在口腔癌细胞中诱导谷胱甘肽，并引起对放射治疗的抵抗。 p62/SQSTM1积累的临床病理学检测可以预测不良预后，并可能成为口腔鳞状细胞癌病例的新生物标志物。

项目成果

診療における新規マーカーの探索と適用

新标志物的寻找及临床应用

• 发表时间: 2012
• 期刊: 臨床病理
• 作者: 小林水緒;角田優子;原田憲一;池田博子;中沼安二;茶野徳宏
• 通讯作者: 茶野徳宏

Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation.

• DOI: 10.1371/journal.pone.0060397
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Isono T;Chano T;Okabe H;Suzaki M
• 通讯作者: Suzaki M

Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.

• DOI: 10.1371/journal.pone.0096168
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Isono T;Chano T;Kitamura A;Yuasa T
• 通讯作者: Yuasa T

Potential of SOX2 Inhibition for Embryonal Carcinoma

SOX2 抑制治疗胚胎癌的潜力

• DOI: 10.1016/j.juro.2011.12.058
• 发表时间: 2012
• 期刊: J Urol
• 作者: Ushida H;Chano T;Minami K;Kita H;Kawakami T;Okabe H;Okada Y;Okamoto K.
• 通讯作者: Okamoto K.

Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application.

• DOI: 10.1371/journal.pone.0032052
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hama Y;Chano T;Inui T;Matsumoto K;Okabe H
• 通讯作者: Okabe H