RB1CC1 and p62/SQSTM1 abnormalities in human carcinogenesis, and their utilities on clinical application

采用肺癌组织芯片对p62/SQSTM 1和RB 1CC 1染色进行评分。RB 1CC 1仅在肺癌细胞质中表达，提示肺癌预后不良。 p62/SQSTM 1的积累与生存率更差相关，尤其是在p62/SQSTM 1和RB 1CC 1同时表达的病例中。 p62/SQSTM 1可能成为肺癌预后不良的生物标志物，在口腔鳞癌中，p62/SQSTM 1参与诱导口腔癌细胞内谷胱甘肽的生成，并导致对放射治疗的抵抗。 p62/SQSTM 1的表达可作为口腔鳞状细胞癌的一个新的生物学标志物。

Staining of p62/SQSTM1 and RB1CC1 was scored by using a tissue microarray of lung cancers. RB1CC1 is expressed only in the cytoplasm of lung cancers, suggesting poor prognosis of lung cancers. p62/SQSTM1 accumulation was further associated with the worse survival, especially the worst in the cases with both expressions of p62/SQSTM1 and RB1CC1. p62/SQSTM1 could become a biomarker of worse prognosis in lung cancer cases.In oral squamous cell carcinomas, p62/SQSTM1 contributed to induce glutathione in oral carcinoma cells, and to cause a resistance to radiation therapy. Clinico-pathological detection of p62/SQSTM1 accumulation could predict poor prognosis, and could be a new biomarker in the cases of oral squamous cell carcinoma.