Analysis for novel genes associating with the resistance and metabolism for the anti-cancer agents

随着抗癌化疗的应用，各种恶性肿瘤包括恶性肿瘤、白血病和肉瘤的预后得到了极大的改善。然而，目前已经成为治疗肿瘤的障碍的是对抗癌剂的多药耐药性问题。为了研究与耐药相关的各种生物学事件，并将其应用于肿瘤的治疗，本研究启动了该项目，在该项目的研究过程中，我们鉴定了5个与耐药相关的候选基因，并在这些基因中发现了一个新的分子RB 1CC 1 RB 1诱导型卷曲螺旋1（RB 1-inducible Coiled-Coil 1）与RB 1（retinoblastoma 1）肿瘤抑制因子密切相关，我们还将RB 1CC 1与各种癌症的发展相关。因此，该新分子RB 1CC 1的功能分析和RB 1CC 1 I基因在癌症中的突变分析主要在项目期的后半部分进行。然后，我们实现了下一页提到的成就。

With the application of anti-cancer chemotherapy, the prognosis of various malignant tumors including cancers, leukemia and sarcomas was greatly improved. However, those, that have presently become the barrier in order to treat the tumors, are the problems of multidrug resistance to anti-cancer agents. In order to the various biological events that are related to the drug resistance, and to apply the obtained findings to the tumor treatments, this research project had been started.In the process of this project, we identified 5 candidate genes relating to the drug resistance, and one novel molecule among the those, RB1CC1 (RB1-inducible Coiled-Coil1), were closely associated with RB1 (retinoblastoma 1) tumor suppressor, and we also related RB1CC1 to the developments of various cancers. Therefore, the functional analysis of this novel molecule RB1CC1, and the mutation analysis of RB1CC1I gene in the cancers were mainly performed at the latter half of the project period. Then, we performed the achievements such as mentioned on the next page.