The predictive ability of endogenous secretory receptor for advanced glycation end products for fragility Fractures and cardiovascular diseases.

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We conducted the 5-year follow-up survey of FORMEN Study which enrolled 2012 men at the baseline, as part of a prospective cohort study of Fujiwara-kyo study. There was no significant difference in esRAGE values at the baseline survey in men who suffered coronary artery diseases when compared to men who did not. The higher values of esRAGE were significantly correlated with the lower values of intima-media thickness of carotid artery (IMT) measured at the 5-year follow-up survey, while there was no significant correlation between esRAGE- to pentosidine ratio and IMT values. Higher values of esRAGE-to-pentosidine ratio were associated with a decreased risk of fragility fractures independently of age and BMD among Japanese elderly men.