The predictive ability of endogenous secretory receptor for advanced glycation end products for fragility Fractures and cardiovascular diseases.

内源性分泌受体对脆性骨折和心血管疾病的晚期糖基化终产物的预测能力。

• 批准号: 24659332
• 负责人: TAMAKI Junko
• 金额: $ 2.58万
• 依托单位: Osaka Medical College (2013)Kinki University (2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659332/
• 关键词: 成人保健; 骨折; 循環器疾患

We conducted the 5-year follow-up survey of FORMEN Study which enrolled 2012 men at the baseline, as part of a prospective cohort study of Fujiwara-kyo study. There was no significant difference in esRAGE values at the baseline survey in men who suffered coronary artery diseases when compared to men who did not. The higher values of esRAGE were significantly correlated with the lower values of intima-media thickness of carotid artery (IMT) measured at the 5-year follow-up survey, while there was no significant correlation between esRAGE- to pentosidine ratio and IMT values. Higher values of esRAGE-to-pentosidine ratio were associated with a decreased risk of fragility fractures independently of age and BMD among Japanese elderly men.

作为Fujiwara-kyo研究前瞻性队列研究的一部分，我们对FORMEN研究进行了为期5年的随访调查，在基线时招募了2012名男性。在基线调查中，患有冠状动脉疾病的男性与没有患冠状动脉疾病的男性相比，esRAGE值没有显著差异。在5年随访调查中，esRAGE值越高，颈动脉内膜-中膜厚度（IMT）值越低，而esRAGE与戊苷比值与IMT值无显著相关性。在日本老年男性中，较高的esRAGE-to-pentosidine比值与脆性骨折风险降低相关，与年龄和骨密度无关。

项目成果

男性骨粗鬆症コホート研究5年次追跡による脆弱性骨折のリスク要因の検討-FORMEN Study

通过男性骨质疏松症队列研究的 5 年随访检查脆性骨折的危险因素 - FORMEN 研究

• 发表时间: 2013
• 作者: T Ogawa;K Zaitsu;T Kokaji;T Suga;M Iwai;H Hattori;H Tsuchihashi;O Suzuki;A Ishii;H Seno;玉置淳子
• 通讯作者: 玉置淳子

Serum Pentosidine and its Decoy Receptor, endogenous secretory receptor for Advanced Glycation End Products, Predict Fragility Fractures in Elderly Men : the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

血清戊糖素及其诱饵受体（高级糖基化终产物的内源性分泌受体）可预测老年男性的脆性骨折：Fujiwara-kyo 男性骨质疏松症风险 (FORMEN) 研究

• 发表时间: 2013
• 作者: T Ogawa;K Zaitsu;T Kokaji;T Suga;M Iwai;H Hattori;H Tsuchihashi;O Suzuki;A Ishii;H Seno;玉置淳子;Tamaki J.
• 通讯作者: Tamaki J.

INCIDENT CLINICAL FRACTURE INCREASES THE RISK OF MORTALITY IN COMMUNITY-DWELLING ELDERLY MEN: FUJIWARA-KYO OSTEOPOROSIS RISK IN MEN (FORMEN) STUDY

意外发生的临床骨折会增加社区老年男性的死亡风险：藤原京男性 (Formen) 研究中的骨质疏松症风险

• 发表时间: 2012
• 作者: Iki M;Fujita Y;Tamaki J; Kouda K;Yura A;Kadowaki E;Sato Y;Moon J.S;Harano A;Hazaki K;Okamoto N;Kurumatani N.
• 通讯作者: Kurumatani N.

高齢男性の新規骨折は生命予後を悪化させる : 藤原京スタディ男性骨粗鬆症研究

老年男性新发骨折使生活预后恶化：Fujiwara Kyo 对男性骨质疏松症的研究

• 发表时间: 2012
• 作者: 伊木雅之

Serum Pentosidine and its Decoy receptor, endogenous secretory receptor for Advanced Glycation End products, Predict Fragility Fractures in Elderly Men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

血清戊糖素及其诱饵受体（高级糖基化终产物的内源性分泌受体）预测老年男性的脆性骨折：Fujiwara-kyo 男性骨质疏松症风险 (FORMEN) 研究

• 作者: Junko TAMAKI;Katsuyasu KOUDA;Yuki FUJITA;Masayuki IKI;Akiko YURA;Eiko KADOWAKI;Masakazu MIURA;Yuho SATO;Nozomi OKAMOTO;Norio KURUMATANI
• 通讯作者: Norio KURUMATANI