Does low bone mass predict atherosclerotic cardiovascular disease? ; 10-year follow-up of a large population-based randomized sampled survey

本研究旨在探讨低骨量是否预示着动脉粥样硬化的增加。2006年，我们对1040名妇女进行了为期10年的随访调查（随访率：68.6%）。我们分析了2006年609名年龄在50岁或以上的女性，测量了颈动脉分叉内膜-中膜厚度（BIF-IMT）。脊柱t评分受试者的调整BIF-IMT值？-1、-2.5 ~ -1之间、<-2.5或常见的椎体骨折分别为1.19mm、1.34mm、1.57mm，绝经≤10年（YSM）女性为1.30mm、1.32mm、1.53mm。10例基线时无高血压病史（线性趋势均p<0.05）。这些相关性与基线时的年龄、BMI、总胆固醇、吸烟和饮酒习惯、糖尿病史和高血压（小于10 YSM组）无关。2007年，我们建立了心血管事件数据库。2006年随访的613名50岁及以上女性中有21例心血管事件。绝经前、围绝经期、YSM<10、YSM ？10、基线时腰椎骨骼状况与心血管事件之间无显著性差异。在调整年龄、体重、身高、总胆固醇与高密度脂蛋白胆固醇之比、高血压、糖尿病史、吸烟习惯等因素后，YSM<10组患者骨质减少与心血管事件的比值比接近36.76 （p=0.073）。对839名受试者进行了类似的分析，包括2006年未参加的受试者，随后进行了一份关于心血管事件信息的问卷调查，两者之间没有显著的关系。骨质疏松症包括普遍的椎体骨折可以预测绝经后妇女颈动脉粥样硬化的未来10年。

This study was conducted to investigate whether low bone mass predicts increased atherosclerosis. In 2006, we conducted a 10-year follow-up survey of 1,040 women (follow-up rate: 68.6%). We analyzed 609 women aged 50 years or older in 2006 whose intima-media thickness of carotid bifurcation (BIF-IMT) was measured. Adjusted BIF-IMT values of subjects with spine T-score ? -1, between -2.5 and -1, and <-2.5 or prevalent vertebral fracture were 1.19mm, 1.34mm, 1.57mm, respectively, in women with less than 10 years since menopause (YSM), 1.30mm, 1.32mm, 1.53mm, in women with YSM ?10 without a history of hypertension at baseline (both with p<0.05 for liner trend). Those associations were independent of age, BMI, total cholesterol, smoking and drinking habits, history of diabetes mellitus, and hypertension (for the less than 10 YSM group) at baseline.In 2007, we set up the database with data of cardiovascular event. There was 21 cardiovascular events among 613 women aged 50 years or older followed in 2006. With multivariate analyses among premenopause, perimenopause, YSM<10, YSM ? 10, there was neither significance between lumbar bone status at baseline and cardiovascular event. Odds ratio of osteopenia for cardiovascular event was near significance of 36.76 (p=0.073) in YSM<10, after adjusting for age, weight, height, ratio of total cholesterol to HDL cholesterol, history of hypertension and diabetes mellitus, and smoking habits, at baseline. With similar analyses among 839 subjects including nonparticipation in 2006 followed by a questionnaire about information regarding cardiovascular event, there was neither significant relationship.Osteoporosis including prevalent vertebral fracture may predict carotid atherosclerosis in the next 10 years in postmenopausal women.