C-reactive protein for risk assessment in the primary prevention of cardiovascular disease : association between effect of life style modification and C-reactive protein

C反应蛋白在心血管疾病一级预防中的风险评估：生活方式改变的影响与C反应蛋白之间的关联

• 批准号: 14570318
• 负责人: TAMAKI Junko
• 金额: $ 2.62万
• 依托单位: Kinki University (2003)Hokkaido University (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570318/
• 关键词: C-reactive protein; Arteriosclerosis; predictive factor; carotid arterie's intima-media thickness; life-style modification; 生活習慣; 生活習慣病; 内臓脂肪; インスリン抵抗性; 動脈硬化; 頚動脈超音波

The association between C-reactive protein(CRP) and an index of internal organs obesity, insulin resistance, and arteriosclerosis of carotid arteries were investigated with 116 healthy Japanese(BMI:15.7〜30.6kg/m^2;15subjects' BMI were between 25〜29.9kg/m^2,2 subjects' BMI were equal or more than 30kg/m^2). Obesity and internal organs fat, CRP, interleukin-6(IL-6), tissue necrosis factor α(TNF-α), carotid artery supersonic intima-media thickness(IMT) were measured and analyzed in cross-sectional design. CRP was related to a fat index in univariate analysis significantly, and CRP was related by waist circumference, waist hips rate, a viscera adipose area and the built-in fat index that said after adjustment in age, sex, smoking. IL-6 and TNF-α were not related to CRP. Blood pressure, metabolic index, CCA-IMT were related with CRP, too. However, in the adjustment for age, sex, smoking, BMI, only blood pressure and HDL-cholesterol were significantly related with CRP.Among healthy Japanese, CRP was related to internal organs obesity and a part of indexes of insulin resistance, but was not related to IL-6 and TNF-α. We examined association between hyper-sensitive CRP, and degree of arterial sclerosis and effect of life-style modification by reviewing available studies in general population systematically. The following points became clear. CRP value foresees the arteriosclerotic disease onset or death independently among healthy middle-aged men and women. However, there was not enough evidence, among a senior citizen older than 80 years old. CRP value was in conjunction with dietary nutrient, and physical activity decreases CRP value, and smoking raises CRP value. In addition, CRP value was related with carotid artery consolidation(hyperplasia of Intima-medica thickness-IMT), and it became dear that there was level of evidence n about drinking of middle equivalence decreasing CRP value again.

对116名日本健康人（BMI：15.7 ~ 30.6kg/m^2; 15名BMI在25 ~ 29.9kg/m^2之间，2名BMI等于或大于30 kg/m^2）进行了C-反应蛋白（CRP）与内脏肥胖指数、胰岛素抵抗和颈动脉粥样硬化的相关性研究。采用横断面设计，对肥胖及内脏脂肪、C反应蛋白（CRP）、白细胞介素-6（IL-6）、组织坏死因子-α（TNF-α）、颈动脉超声内中膜厚度（IMT）进行检测分析。单因素分析中CRP与体脂指数相关显著，且CRP与腰围、腰臀率、内脏脂肪面积及内脂肪指数相关，校正年龄、性别、吸烟后CRP与内脂肪指数相关。IL-6、TNF-α与CRP无相关性。血压、代谢指标、颈动脉内膜中层厚度也与CRP相关。在调整了年龄、性别、吸烟、BMI等因素后，只有血压和HDL-胆固醇与CRP显著相关，在日本健康人群中，CRP与内脏肥胖和部分胰岛素抵抗指标相关，而与IL-6和TNF-α无关。我们通过系统地回顾现有的普通人群研究，研究了超敏CRP与动脉硬化程度和生活方式改变的关系。以下几点变得很清楚。在健康的中年男性和女性中，CRP值可独立预测动脉粥样硬化疾病的发生或死亡。然而，在一位80岁以上的老年人中，没有足够的证据。CRP值与膳食营养有关，体力活动降低CRP值，吸烟升高CRP值。此外，CRP值与颈动脉实变（IMT增生）有关，中等当量饮酒降低CRP值的证据再次明确。

项目成果

岸玲子, 西條泰明: "ストレス回避"毎日ライフ. 5. 45-47 (2002)

Reiko Kishi、Yasuaki Saijo：“避免压力”《每日生活》5. 45-47 (2002)。

岸玲子, 西條泰明: "心臓・血管病の危険因子ストレス"すこやかハート. 81. 2-4 (2002)

Reiko Kishi、Yasuaki Saijo：“心脏和血管疾病的危险因素压力”健康心脏 81. 2-4 (2002)。

玉置淳子, 菊池有利子, 由田克士, et al.: "行動変容ステージとそれに関連する因子の検討-High Risk and Population Strategy for Occupational Health Promotion study (HI-POP-OHP study) ベースラインデータより"第13回日本疫学会抄録集. (in press).

Junko Tamaki、Yoshiko Kikuchi、Katsushi Yuda 等：“从基线数据检查行为改变阶段和相关因素——职业健康促进研究（HI-POP-OHP 研究）的高风险和人群策略”第 13 期摘要日本流行病学会（正在出版）。

Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M, Kishi R: "Relationship between C-reactive Protein and Visceral Adipose Tissue in Healthy Japanese Subjects"Diabetes, Obesity, and Metabolism. (in press).

Saijo Y、Kiyota N、Kawasaki Y、Miyazaki Y、Kashimura J、Fukuda M、Kishi R：“健康日本受试者中 C 反应蛋白与内脏脂肪组织的关系”糖尿病、肥胖和代谢。

Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Pukuda M, Kishi R: "Relationship between C-reactive Protein and Visceral Adipose Tissue in Healthy Japanese Subjects"Diabetes, Obesity, and Metabolism. (in press).

Saijo Y、Kiyota N、Kawasaki Y、Miyazaki Y、Kashimura J、Pukuda M、Kishi R：“健康日本受试者中 C 反应蛋白与内脏脂肪组织的关系”糖尿病、肥胖和代谢。