Cell therapy of adipocytes derived from human iPS cells using cellcontainers and animal disease models

使用细胞容器和动物疾病模型对源自人类 iPS 细胞的脂肪细胞进行细胞治疗

• 批准号: 24659444
• 负责人: HOSODA Kiminori
• 金额: $ 2.41万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659444/
• 关键词: 脂肪細胞; iPS細胞; 脂肪萎縮症; 細胞治療; ヌードマウス

We investigated the function of adipocyte derived from human iPS and ES cells and the survival and maintenance of these cells after transplantation into nude mice. The adipocytes derived from human iPS and ES cells showed adipocyte function such as lipolysis, and survived at least 4 weeks after the transplantation. The adipogenic differentiation and transplantation system in vitro and in vivo is expected to be useful in the study of pathophysiology and to be applied for future cell therapy.

我们研究了人iPS细胞和胚胎干细胞提取的脂肪细胞的功能，以及这些细胞移植到裸鼠体内后的存活和维持情况。来源于人iPS和ES细胞的脂肪细胞表现出脂肪分解等脂肪细胞功能，并在移植后存活至少4周。体外和体内的脂肪分化和移植系统有望在病理生理学研究和未来的细胞治疗中应用。

项目成果

ヒト ips 細胞由来の脂肪細胞の脂肪細胞機能解析と細胞移植

人IPS细胞来源的脂肪细胞的脂肪细胞功能分析和细胞移植

• 发表时间: 2012
• 作者: 野口倫生;細田公則;他.
• 通讯作者: 他.

Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy

• DOI: 10.1210/jc.2012-1872
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• 影响因子: 5.8
• 作者: Aotani, Daisuke;Ebihara, Ken;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)

• DOI: 10.2183/pjab.88.454
• 发表时间: 2012-10-01
• 期刊: PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
• 影响因子: 3.1
• 作者: Nakao, Yoko M.;Miyawaki, Takashi;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome:

腹内脂肪面积是代谢综合征各个组成部分新发的预测因子：

• 发表时间: 2012
• 期刊: Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
• 作者: Nakao YM;Hosoda K;et al
• 通讯作者: et al

ヒトiPS細胞由来脂肪細胞の分化誘導と細胞移植

人iPS细胞来源的脂肪细胞的分化诱导和细胞移植

• 作者: 野口倫生;細田公則;森栄作;松原正樹;田浦大輔;曽根正勝;藤倉純二;海老原健;中尾一和
• 通讯作者: 中尾一和