Cholesterol ointment suppressed hapten-induced dermatitis by inducing 11B-HSD1

胆固醇软膏通过诱导 11B-HSD1 抑制半抗原诱导的皮炎

• 批准号: 24659529
• 负责人: KATAYAMA ICHIRO
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659529/
• 关键词: アトピー性皮膚炎; 皮膚バリア; コレステロール; 脂質; コルチゾール; 11β-HSD1; 表皮角化細胞; 保湿剤; 皮膚バリア機能; 接触皮膚炎; QOL、ステロイド外用薬; バリア機能改善・抗炎症作用外用剤

Changes in the stratum corneum extracellular matrix impair epidermal barrier function and may cause dermatoses in atopic dermatitis patients and elderly people. The aim of this study was to examine the effect of exogenous cholesterol application on skin barrier function and cutaneous inflammation. Hapten-stimulated mice were treated with topical cholesterol. The effect of topical cholesterol application on an oxazolone (OXA)-induced hypersensitivity reaction was evaluated. Topical application of cholesterol efficiently decreased transepidermal water loss in areas of barrier-disrupted skin and ameliorated OXA-induced cutaneous hypersensitivity. These favourable effects may have resulted from sustained expression of 11beta-hydroxysteroid dehydrogenase type 1 (11B-HSD1) in the cholesterol-treated skin. As 11B-HSD1 is known to produce active cortisol, topical cholesterol may attenuate contact hypersensitivity by normalizing secretion of hormonally active cortisol from the skin.

在特应性皮炎患者和老年人中，角质层细胞外基质的变化损害表皮屏障功能，并可能导致皮肤病。本研究的目的是检查外源性胆固醇应用对皮肤屏障功能和皮肤炎症的影响。用局部胆固醇处理半抗原刺激的小鼠。评价了局部应用胆固醇对恶唑酮（OXA）诱导的超敏反应的影响。局部应用胆固醇有效地降低了经皮水分流失的地区的屏障破坏的皮肤和改善OXA诱导的皮肤过敏。这些有利的效果可能是由于胆固醇处理的皮肤中11 β-羟基类固醇脱氢酶1型（11B-HSD 1）的持续表达。由于已知11B-HSD 1可产生活性皮质醇，局部胆固醇可通过使皮肤分泌的皮质醇正常化来减轻接触性超敏反应。

项目成果

Topical cholesterol application ameliorates hapten-evoked cutaneous hypersensitivity by sustaining expression of 11βHSD-1 in epidermis

局部应用胆固醇可通过维持表皮中 11βHSD-1 的表达来改善半抗原诱发的皮肤过敏

• 发表时间: 2013
• 作者: H Murota;M Terao;S Matsui;H Kawai;Y Satou;K Suda;I Katayama
• 通讯作者: I Katayama

Expression profiles of cortisol inactivating enzyme, 11β-hydroxysteroid dehydrogenase 1 and 2 in human epidermal tumors and its role in keratinocyte proliferation.

皮质醇失活酶、11β-羟基类固醇脱氢酶1和2在人表皮肿瘤中的表达谱及其在角质形成细胞增殖中的作用。

• 发表时间: 2013
• 作者: Mika Terao;Hiroyuki Murota; Ichiro Katayama
• 通讯作者: Ichiro Katayama

Decreased Sudomotor Function is Involved in the Formation of Atopic Eczema in the Cubital Fossa

催汗功能下降与肘窝特应性湿疹的形成有关

• DOI: 10.2332/allergolint.13-oa-0547
• 发表时间: 2013
• 期刊: Allergology International
• 影响因子: 6.8
• 作者: Takahashi A;Murota H;Matsui S;Kijima A;Kitaba S;Lee JB;Katayama I.
• 通讯作者: Katayama I.

Positive link between STAT3 activation and Th17 cell infiltration to the lesional skin in vitiligo vulgaris.

• DOI: 10.1016/j.jdermsci.2012.06.010
• 发表时间: 2012-09
• 期刊: Journal of dermatological science
• 影响因子: 4.6
• 作者: A. Tanemura;Y. Kotobuki;Saori Itoi;T. Takata;S. Sano;I. Katayama

Topical Vitamin D3 Therapy for Steroid Resistant Prurigo: Anti-inflammatory Action or Neuroprotective Effect

局部维生素 D3 治疗类固醇耐药性痒疹：抗炎作用或神经保护作用

• 发表时间: 2013
• 作者: Ichiro Katayama;Mika Terao;Mayuko Nakano;SJ Bae;Hiroyuki Murota
• 通讯作者: Hiroyuki Murota