Protective effects of a combination of multiple pharmaceutical drugs on the survival of mice exposed to lethal ionizing radiation

点击翻译按钮获取中文摘要

Different combinations of four drugs - recombinant human erythropoietin (EPO), granulocyte-colony stimulating factor (G-CSF), c-mpl receptor agonist romiplostim (RP) and nandrolone decanoate (ND)- was administered to mice within 2 h after exposure to a lethal 7 Gy dose of gamma-irradiation.Approximately 10% of the untreated irradiated control mice survived for 27 days, but all of the control mice died by day 30. The combined administration of G-CSF, EPO and RP for three days immediately after irradiation led to a complete survival of the irradiated mice until day 30.However,the treatment with G-CSF and EPO with ND led to only 75% survival at day 30.The hematological analyses showed that the numbers of almost of hematopoietic cells in the surviving mice treated with effective medications recovered to the levels of non-irradiated mice.The present findings show that the combination of G-CSF, EPO and RP may be a useful countermeasure for victims exposed to accidental lethal irradiation.