Analysis for disease mechanism by intracellular elements using microparticle beam

利用微粒束分析细胞内元素的疾病机制

• 批准号: 24659556
• 负责人: SAKURAI Hideyuki
• 金额: $ 2.41万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659556/
• 关键词: 量子ビーム

In the present generation, the trace elements are taken in human body and these cause several disease. The trace elements have shown close correlation of treatment resistant disease, such as Parkinson disease. In cancer therapy, some trace elements are used as an anticancer agent. In this research, mechanisms of disease & treatment effect are analyzed by measuring trace element distribution in cell. In analysis for sample from atypical pneumonia, many elements, such as iron, nickel, chromium, aluminium, were seen simultaneously as one image. By using cultured cells in vitro, uptake of cis-platinum to cells were seen, and amount of platinum could be estimated. This study is useful for scientific diagnosis for treatment resistant disease in recent society.

在当代中，痕量元素是在人体中采取的，这些元素会引起多种疾病。痕量元素已经显示出抗治疗疾病的密切相关性，例如帕金森氏病。在癌症治疗中，一些痕量元素用作抗癌剂。在这项研究中，通过测量细胞中的痕量元素分布来分析疾病和治疗效果的机制。在非典型肺炎样品的分析中，许多元素，例如铁，镍，铬，铝，被视为一个图像。通过在体外使用培养的细胞，可以看到顺铂对细胞的摄取，可以估计铂的量。这项研究对于最近社会的科学诊断很有用。

项目成果

Evaluation of vegetables in Tsukuba for contamination with radioactive materials from the accident at Fukushima Daiichi nuclear power pl

对筑波蔬菜受福岛第一核电站事故放射性物质污染的评估

• DOI: 10.1097/hp.0b013e3182895759
• 发表时间: 2013
• 期刊: Health Phys
• 影响因子: 2.2
• 作者: Isobe T;Mori Y;Takada K;Sato E;Takahashi H;Sekiguchi T;Yoshimura Y;Sakurai H;Sakae T
• 通讯作者: Sakae T

Suprasellar GCT and endocrinopathy;duration of symptoms and outcome

鞍上 GCT 和内分泌病；症状持续时间和结果

• 发表时间: 2013
• 作者: Fukushima H;et al
• 通讯作者: et al

Quantitative assessment of 131-1 in soil originating from the Fukushima Daiichi Nuclear Power Plant Disaster using a germanium semiconductor detector

使用锗半导体探测器对福岛第一核电站灾难土壤中的 131-1 进行定量评估

• 发表时间: 2013
• 作者: Aihara T;et al;K Yamanashi,H Kumada,K Takada,H Sakurai,T Sakae;K Takada,T Isobe,H Kumada,K Yamanashi,H Sakurai,T Sakae;R Suzuki,T Fukushima,C Kobayashi,H Fukushima,A Sakai,T Ishida,T Ohsumi,H Ochiai,S Kishimoto,M Chin,R Hosogai,Y Hosoya,A Watanabe,C Goto,K Masumoto,M Mizumoto,H Sakurai,R Sumazaki;T Okumura,K Fukuda,T Hashimoto,M Mizumoto,H Ishikawa,T Sakae,M Abei,K Tsuboi,H Sakurai;Y Mori,T Isobe,K Takada,S Kamizawa,E Sato,H Sakurai,T Sakae
• 通讯作者: Y Mori,T Isobe,K Takada,S Kamizawa,E Sato,H Sakurai,T Sakae

The basic evaluation of radiation exposure dose for whole body in clinical boron neutron capture therapy

临床硼中子俘获治疗全身辐射剂量的基本评价

• 发表时间: 2013
• 作者: Aihara T;et al;K Yamanashi,H Kumada,K Takada,H Sakurai,T Sakae;K Takada,T Isobe,H Kumada,K Yamanashi,H Sakurai,T Sakae
• 通讯作者: K Takada,T Isobe,H Kumada,K Yamanashi,H Sakurai,T Sakae

Evaluation of the radiation dose for whole body in boron neutron capture therapy

硼中子俘获治疗全身辐射剂量的评价

• 发表时间: 2012
• 作者: Takada K;et al
• 通讯作者: et al