Analysis for disease mechanism by intracellular elements using microparticle beam

利用微粒束分析细胞内元素的疾病机制

• 批准号: 24659556
• 负责人: SAKURAI Hideyuki
• 金额: $ 2.41万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659556/
• 关键词: 量子ビーム

In the present generation, the trace elements are taken in human body and these cause several disease. The trace elements have shown close correlation of treatment resistant disease, such as Parkinson disease. In cancer therapy, some trace elements are used as an anticancer agent. In this research, mechanisms of disease & treatment effect are analyzed by measuring trace element distribution in cell. In analysis for sample from atypical pneumonia, many elements, such as iron, nickel, chromium, aluminium, were seen simultaneously as one image. By using cultured cells in vitro, uptake of cis-platinum to cells were seen, and amount of platinum could be estimated. This study is useful for scientific diagnosis for treatment resistant disease in recent society.

在当代，微量元素被摄入人体，并导致多种疾病。微量元素与帕金森病等难治性疾病有密切关系。在癌症治疗中，一些微量元素被用作抗癌剂。本研究通过测定微量元素在细胞内的分布，分析其发病机理和治疗效果。在对非典型肺炎标本的分析中，铁、镍、铬、铝等多种元素同时出现在一个图像上。通过使用体外培养的细胞，观察到顺铂被细胞摄取，并且可以估计铂的量。本研究为当今社会对难治性疾病的科学诊断提供了依据。

项目成果

婦人科領域癌の骨盤内再発腫瘍に対する組織内照射

妇科癌症盆腔复发肿瘤的组织内照射

• 发表时间: 2013
• 作者: 沼尻晴子;大川綾子;瀧澤大地;牧島弘和;大野豊然貴;水本斉志;大西かよ子;石川仁;奥村敏之 and 櫻井英幸
• 通讯作者: 奥村敏之 and 櫻井英幸

Long-term survival in patients with hepatocellular carcinoma initially treated with definitive proton beam therapy

最初接受根治性质子束治疗的肝细胞癌患者的长期生存

• 发表时间: 2013
• 作者: T. Okumura;K. Fukuda;T. Hashimoto;M. Mizumoto;H. Ishikawa;T. Sakae;M. Abei;K. Tsuboi and H. Sakurai
• 通讯作者: K. Tsuboi and H. Sakurai

Boron-neutron capture therapy for newly diagnosed head and neck cancer in initial treatment

新诊断的头颈癌初始治疗中的硼中子俘获疗法

• 发表时间: 2013
• 作者: Aihara T;Morita N;Kamitani N;Kumada H;Fukumitsu N;Sakurai Y;Ohnishi K;Hiratsuka J;Sakurai H
• 通讯作者: Sakurai H

ROBUST TECHNIQUE USING AN IMAGING PLATE TO DETECT ENVIRONMENTAL RADIOACTIVITY

• DOI: 10.1097/hp.0b013e31827d41a9
• 发表时间: 2013-04-01
• 期刊: HEALTH PHYSICS
• 影响因子: 2.2
• 作者: Isobe, Tomonori;Mori, Yutaro;Sakae, Takeji
• 通讯作者: Sakae, Takeji

Advances in highly conformal radiotherapy for prostate cancer : past, current, and future

前列腺癌高度适形放射治疗的进展：过去、现在和未来

• 发表时间: 2012
• 期刊: Igaku Butsuri
• 作者: Ishikawa H;Hashimoto T;他4名
• 通讯作者: 他4名