A translational research for promotion of multimodality therapy combined with proton beam therapy

促进多学科治疗联合质子束治疗的转化研究

• 批准号: 21390338
• 负责人: SAKURAI Hideyuki
• 金额: $ 9.82万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390338/
• 关键词: 陽子線治療; 集学的治療; 化学放射線療法; 抗腫瘍効果; 併用療法; 科学放射線療法; 小児がん

The aim of this study is to promote translational research for multimodality therapy combined with proton beam therapy (PBT). We found increasing radiobiological effect on late phase of bragg peak, and also detected apoptosis in the crypt cells irradiated with very low dose of proton. For normal tissue reaction, dose-volume relationship was clearly found both in rib fracture on PBT for liver cancer and in pneumonistis on PBT combined with chemotherapy for advanced lung cancer. Finally, from these translational researches, we have started clinical trials for advanced lung cancer and pediatric cancer as a multimodality therapy combined with PBT.

这项研究的目的是促进多模式治疗与质子束治疗(PBT)相结合的翻译研究。我们发现Bragg峰晚期的放射生物学效应增强，并在极低剂量的质子照射下检测到隐窝细胞的凋亡。对于正常的组织反应，无论是肝癌的PBT肋骨骨折，还是晚期肺癌PBT联合化疗的肺炎，都存在明显的剂量-体积关系。最后，通过这些转化性研究，我们已经开始了晚期肺癌和儿童癌症的临床试验，作为一种结合PBT的多模式治疗。

项目成果

A phase I/II clinical trial of hyperfractionated concomitant boost protonradiotherapy for supratentorial glioblastoma multiforme.

超分割伴随增强质子放射治疗幕上多形性胶质母细胞瘤的 I/II 期临床试验。

• 发表时间: 2009
• 作者: Koji Tsuboi;Masashi Mizumoto;Hiroshi Igaki;Tetsuya Yamamoto;Shingo Takano;Toshiyuki Okumura;Hideyuki Sakurai
• 通讯作者: Hideyuki Sakurai

Proton beam therapy for intrahepatic cholangio carcinoma

质子束治疗肝内胆管癌

• 发表时间: 2010
• 作者: Ohkawa A;et al
• 通讯作者: et al

Efficacy and limitation of radiation therapy for hepatocellular carcinoma complicated with liver cirrhosis.

放射治疗肝细胞癌并发肝硬化的疗效和局限性。

• 发表时间: 2011
• 作者: Abei M;et al
• 通讯作者: et al

放射線障害防護剤

辐射防护剂

• 发表时间: 2010

Influence of Neutron Generated in 10 MV-X-ray Irradiation and Proton Beam on Implatable Cardioverter Defibrillators (ICDs).

10 MV-X 射线照射和质子束产生的中子对植入式心脏复律除颤器 (ICD) 的影响。

• 发表时间: 2010
• 作者: Isobe T;et al
• 通讯作者: et al