Developing microRNA research in cardiac failure

开展心力衰竭的 microRNA 研究

• 批准号: 24659632
• 负责人: SAWA Yoshiki
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659632/
• 关键词: 重症心不全; 心房細動; microRNA; 再生医学; 核酸

Little is known about microRNA expression in the cardiac tissue of chronic cardiac pathologies. In this study, we investigated relationship between microRNA expression and cardiac pathology in the left ventricular tissue of end-stage cardiac failure patients who completed "bridge to transplantation" using mechanical circulatory support and in the right atrial tissue of chronic atrial fibrillation. As a result, mechanical circulatory supported induced cardiac functional recovery, increase of microvacular number and expression of miR-21 and miR-29b. Furthermore, miR-21 was highly expressed in the atrial tissue of atrial fibrillation, compared to that of sinus rhythm and this was significantly correlated with the degree of fibrosis in the atrial tissue. These results possibly indicated important role of microRNA expression in the cardiac tissue in the progression of the pathology.

关于慢性心脏病变的心脏组织中microRNA的表达知之甚少。在这项研究中，我们研究了使用机械循环支持完成“移植桥”的终末期心力衰竭患者左心室组织和慢性房颤右心房组织中microRNA表达与心脏病理的关系。结果，机械循环支持诱导心功能恢复，微空泡数量增加，miR-21和miR-29b表达增加。此外，与窦性心律相比，miR-21在心房颤动的心房组织中高表达，这与心房组织纤维化程度显著相关。这些结果可能提示心脏组织中microRNA表达在病理进展中的重要作用。

项目成果

Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery.

• DOI: 10.1371/journal.pone.0073397
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nishi H;Sakaguchi T;Miyagawa S;Yoshikawa Y;Fukushima S;Saito S;Ueno T;Kuratani T;Sawa Y
• 通讯作者: Sawa Y

Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm.

• DOI: 10.1161/jaha.112.000745
• 发表时间: 2012-10
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Kin K;Miyagawa S;Fukushima S;Shirakawa Y;Torikai K;Shimamura K;Daimon T;Kawahara Y;Kuratani T;Sawa Y
• 通讯作者: Sawa Y

Initial report of bridge to recovery in a patient with DuraHeart LVAD

DuraHeart LVAD 患者康复的初步报告

• DOI: 10.1007/s10047-013-0704-6
• 发表时间: 2013
• 期刊: J Artif Organs
• 影响因子: 1.3
• 作者: Yoshioka D;Toda K;Sakaguchi T;Miyagawa S;Nishi H;Yoshikawa Y;Fukushima S;Saito S;Saito T;Shibasaki I;Sakata Y;Ohtani T;Sawa Y
• 通讯作者: Sawa Y

Predictor of Early Mortality for Severe Heart Failure Patients With Left Ventricular Assist Device Implantation

植入左心室辅助装置的严重心力衰竭患者早期死亡率的预测因素

• DOI: 10.1253/circj.cj-11-1452
• 发表时间: 2012
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Yoshioka D;Sakaguchi T;Saito S;Miyagawa S;Nishi H;Yoshikawa Y;Fukushima S;Saito T;Daimon T;Ueno T;Kuratani T;Sawa Y.
• 通讯作者: Sawa Y.

Effect of continuous-flow mechanical support on microvasculature remodeling in the failing heart

连续流机械支持对衰竭心脏微血管重塑的影响

• 期刊: In preparation
• 作者: Saito T;Miyagawa S;Nishi H;Yoshikawa Y;Fukushima S;Yoshioka D;Harada A;Toda K;Sawa Y
• 通讯作者: Sawa Y