Developing microRNA research in cardiac failure

关于microRNA在慢性心脏病的心脏组织中的表达知之甚少。在这项研究中，我们研究了microRNA表达与心脏病理学之间的关系，在终末期心力衰竭患者的左心室组织中，他们使用机械循环支持完成了“移植桥”，以及在慢性房颤的右心房组织中。结果表明，机械循环支持诱导的心脏功能恢复，微血管数量增加，miR-21和miR-29 b表达增加。此外，与窦性心律相比，miR-21在房颤的心房组织中高表达，并且这与心房组织中的纤维化程度显著相关。这些结果可能表明心肌组织中microRNA表达在病理进展中的重要作用。

Little is known about microRNA expression in the cardiac tissue of chronic cardiac pathologies. In this study, we investigated relationship between microRNA expression and cardiac pathology in the left ventricular tissue of end-stage cardiac failure patients who completed "bridge to transplantation" using mechanical circulatory support and in the right atrial tissue of chronic atrial fibrillation. As a result, mechanical circulatory supported induced cardiac functional recovery, increase of microvacular number and expression of miR-21 and miR-29b. Furthermore, miR-21 was highly expressed in the atrial tissue of atrial fibrillation, compared to that of sinus rhythm and this was significantly correlated with the degree of fibrosis in the atrial tissue. These results possibly indicated important role of microRNA expression in the cardiac tissue in the progression of the pathology.