Metabolic modification of mesenchymal stromal cells for harnessing their immunoregulatory capacity in graft-versus-host disease (B06)

间充质基质细胞（MSC）是用于管理治疗抗性GvHD的有前途的治疗剂。新出现的证据表明，新陈代谢决定了细胞的功能，因此是微调生物功能的理想工具。我们的假设是，代谢过程控制免疫调节和骨髓间充质干细胞的再生特性。我们希望探索MSC的代谢调节作为支持其耐受促进能力的手段，特别是考虑到其在GvHD中的临床应用。接受炎症信号的MSC的代谢谱将帮助我们干扰其代谢框架，以进一步改善有益特征。

Mesenchymal stromal cells (MSCs) are promising therapeutics for managing treatment-resistant GvHD. Emerging evidence suggests that metabolism determines what a cell does and thereby represents an ideal tool for fine tuning biologic functions. Our hypothesis is that metabolic processes control immune regulatory and regenerative properties of MSCs. We want to explore metabolic modulation of MSCs as a mean for bolstering their tolerance-promoting capacity especially in view of their clinical use in GvHD. Metabolic profiling of MSCs receiving inflammatory signals will help us in interfering with their metabolic framework for further improving beneficial features.