In search for shared regulatory mechanisims of bone mineralization in vertebrates
In search for shared regulatory mechanisims of bone mineralization in vertebrates
批准号:
24659685
负责人:
MATSUO Koichi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
We generated transgenic medaka fish expressing mouse Fra-1 in osteoblasts to determine cell-autonomous function of Fra-1 in osteoblasts in vivo. Alizarin complexone staining and micro-computed tomography revealed that Fra-1 transgenic medaka showed lower bone mineral density than wild-type controls. These data suggest that Fra-1 expression in osteoblasts impairs bone mineralization not only in mice but also in medaka.
期刊论文(7)
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DOI:
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发表时间:
2013
期刊:
影响因子:
--
作者:
[Matsumoto, T., Takada, Y., Nakamura, T., Suematsu, M., Inohaya, K., Kudo, A., Shimizu, A., and Matsuo, K., 松尾光一]
通讯作者:
松尾光一
Transgenic expression of mouse Fra-1 in osteoblasts reduces bone mineralization in medaka fish.
小鼠成骨细胞中 Fra-1 的转基因表达降低了青鳉鱼的骨矿化。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Matsumoto, T., Takada, Y., Nakamura, T., Suematsu, M., Inohaya, K., Kudo, A., Shimizu, A., and Matsuo, K.]
通讯作者:
K.
Transgenic expression of mouse Fra-1 in osteoblasts reduces bone mineralization in medaka fish
小鼠成骨细胞中 Fra-1 的转基因表达降低了青鳉鱼的骨矿化
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Matsumoto, T., Takada, Y., Nakamura, T., Suematsu, M., Inohaya, K., Kudo, A., Shimizu, A., and Matsuo, K]
通讯作者:
K
Impaired Bone Mineralization In Transgenic Medaka Fish Expressing Fra-1 In Osteoblasts
成骨细胞表达 Fra-1 的转基因青鳉鱼的骨矿化受损
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Matsumoto, T., Takada, Y., Nakamura, T., Suematsu, M., Inohaya, K., Kudo, A., Shimizu, A. and Matsuo, K]
通讯作者:
K
Pericapillary Bone Formation by Mural Osteoblasts during Endochondral Ossification
软骨内骨化过程中壁成骨细胞形成毛细血管周围骨
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Ichiro Takada, Nobuhito Nango, Yoshihiro Takeda, Atsushi Momose, Yoshiaki Kubota, Sho Kanzaki, Kouji Shimoda, Yasunari Takada, Latifa Bakiri, Erwin Wagner, and Koichi Matsuo]
通讯作者:
and Koichi Matsuo
共 7 条
Osteogenic capillaries - new aspect of endochondral ossification
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批准号:17H04015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2017
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负责人:MATSUO Koichi
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依托单位:
Elucidating mechanisms of altered bone matrix mineralization
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批准号:26670674
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:MATSUO Koichi
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依托单位:
Elucidating mechanisms of non-cell-autonomous osteoblast activation
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批准号:25293327
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2013
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负责人:MATSUO Koichi
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依托单位:
New developments in structural analysis of protens by synchrotron-radiation vacuum-ultraviolet circular dichroism
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批准号:23687020
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$8.57万
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财政年份:2011
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负责人:MATSUO Koichi
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依托单位:
Tripartite relationship between osteoclasts, osteoblasts and osteocytes in bone remodeling
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批准号:21390425
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.32万
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财政年份:2009
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负责人:MATSUO Koichi
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依托单位:
Molecular Analysis of Initiation and Termination in Bone Formation
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批准号:19390399
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2007
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负责人:MATSUO Koichi
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依托单位:
Analysis of Bone Remodeling using Osteopetrotic and Osteosclerotic Mouse Models
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批准号:17390420
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.98万
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财政年份:2005
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负责人:MATSUO Koichi
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依托单位:
国内基金
海外基金
板栗采后“石灰化”发生机理研究
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批准号:30871760
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项目类别:面上项目
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资助金额:34.0万元
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批准年份:2008
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负责人:顾采琴
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依托单位: