The development of objective evaluation of pain

疼痛客观评估的发展

• 批准号: 24659696
• 负责人: MASHIMO Takashi
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659696/
• 关键词: 痛みの客観的評価; 脳波; 末梢循環; 誘発電位; パルスオキシメーター; 痛みの評価法; 国際研究者交流; 国際情報交換

When we evaluate our patients' amount of pain, we have referred their self-reported pain until now.Of course we treat their pain using decided some of analgesics, but we have not enough considered of individual differences in pain sensitivity and in threshold of side effects. To resolve this situation, we need to develop the objective measurement tool for the amount of pain. Towards this end, we conducted a study to develop the algorithm of objective evaluation of pain using physiological indices of human beings.Firstly, we revealed the feature of physiological parameter especially about the difference between age and sex using EEG and pulse-oxmeter. The algorithm which extracted from EEG data is currently being prepared to do patent application. Moreover, we revealed that the perfusion index, which is an index reflecting the peripheral circulation, might be a good indicator when we evaluate the pain by the stimulation to the extent that the pulse rate did not change.

我们在评估患者的疼痛程度时，一直是参考患者的自我报告疼痛，当然我们也会使用一些确定的止痛药来治疗疼痛，但我们没有充分考虑到疼痛敏感性和副作用阈值的个体差异。为了解决这种情况，我们需要开发疼痛量的客观测量工具。为此，我们进行了一项基于生理指标的疼痛客观评价算法的研究。首先，我们利用EEG和脉搏血氧仪揭示了生理参数的特征，特别是年龄和性别的差异。从脑电数据中提取的算法目前正在准备申请专利。此外，我们发现，灌注指数，这是一个反映外周循环的指标，可能是一个很好的指标，当我们评价疼痛的刺激，脉搏率没有改变的程度。

项目成果

Cognitive Neuroscience Robotics

认知神经科学机器人

• 发表时间: 2014
• 作者: 福井 聖;岩下 成人;新田 一仁;他、;Aya Nakae
• 通讯作者: Aya Nakae

Contact heat evoked potentials (CHEPs) in healthy subjects–no laterality effect

健康受试者的接触热诱发电位 (CHEP) – 无偏侧效应

• 发表时间: 2014
• 作者: Yelena Granovsky;Praveen Anand;Aya Nakae;Osvaldo Nascimento;Benn Smith;Josep Valls-Sole;David Yarnitsky
• 通讯作者: David Yarnitsky

Mechanisms of Pain". Text book"Cognitive Neuroscience of Robotics"

疼痛机制》。教科书《机器人认知神经科学》

• 发表时间: 2014
• 作者: Aya Nakae A;Thomas Hermann;Takashi Ikeda;Teruko Sakurai;Tomonori Adachi;Hiroshi Ito;Toshiki Nishimura;Masahiko Shibata;Mariko Osaka;Takashi Mashimo;Aya Nakae
• 通讯作者: Aya Nakae

Age-related and sex-related changes in perfusion index in response to noxious electrical stimulation in healthy subjects

• DOI: 10.2147/jpr.s57140
• 发表时间: 2014-01-01
• 期刊: JOURNAL OF PAIN RESEARCH
• 影响因子: 2.7
• 作者: Nishimura, Toshiki;Nakae, Aya;Fujino, Yuji
• 通讯作者: Fujino, Yuji

Correlation between changes in brain activity and subjective pain intensity under sedation by using the contact heat-evoked potential method

接触热诱发电位法研究镇静状态下脑活动变化与主观疼痛强度的相关性

• 发表时间: 2014
• 作者: Aya Nakae;Satoshi Hagihira;Hiroshi Ito;Piyasak Vitrabrananont;Kan Hongling; Yuji Fujino
• 通讯作者: Yuji Fujino