Does local anesthetics induce apoptosis in the developing central nervous system ?

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In order to examine the differences in the toxicity of local anesthetics to the immature and mature brain, adult rats (8 w-old) and neonates (PO7-21) were used. Electrodes for measuring electroencephalograhy were implanted, and a PE10 catheter was inserted into the external jugular vein. Then intravenous infusion of lidocaine was started. When seizure and respiratory arrest were seen, cerebrospinal fluid and arterial blood were collected. The concentrations of lidocaine in the plasma and cerebrospinal fluid were significant higher than those in the adult rats. The results suggest that the developing brain in the rat is resistant to systemic toxicity of local anesthetics, compared to the mature brain.