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Identification of endometrial cancer stem cell markers

Identification of endometrial cancer stem cell markers
子宫内膜癌干细胞标志物的鉴定
批准号:
24659736
负责人:
KATO Kiyoko
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

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中文摘要
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英文摘要
We analyzed the association with dbpC/contrin(dbpC) and the character of endometrial cancer stem cells .We designed and constructed a cytomegarovirus vector containing dbpC cDNA, and transfected it into Ishikawa(IK) cells, an endometrial cancer cell line. The expression of ALDH1 was increased in IK-dbpC cells, compared to mock cells,and the ratio of SP cells were more than 10-fold in IK-dbpC cells compared to mock cells . Downreguration of dbpC expression was remarkably reduced the ALDH1 expression and the rate of SP cells, compared to negative control. Microarray analysis showed that one of the cancer/testis antigens was up-regulated in IK-dbpC cells compared with mock cells.
期刊论文(31)
专著(0)
科研奖励(0)
会议论文
産婦人科における幹細胞研究
干细胞在妇产科的研究
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Shintaku H, Inaoka T, Nakagawa T, Kawano S, Ito J., 加藤聖子]
通讯作者: 加藤聖子
DOI: 10.1177/0960327111424305
发表时间: 2012-06-01
期刊: HUMAN & EXPERIMENTAL TOXICOLOGY
影响因子: 2.8
作者: [Fukushima, K., Tsukimori, K., Wake, N.]
通讯作者: Wake, N.
子宮内膜、子宮体癌幹細胞の同定と生物学的特性の解析
子宫内膜及子宫内膜癌干细胞生物学特性的鉴定与分析
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Yusuf N, Inagaki T, Kusunoki S, Okabe H, Yamada I, Matsumoto A, Terao T, Takeda S, Kato K, Kiyoko Kato, 加藤聖子, 加藤聖子]
通讯作者: 加藤聖子
DOI: 10.1016/j.ygyno.2013.03.005
发表时间: 2013-06-01
期刊: GYNECOLOGIC ONCOLOGY
影响因子: 4.7
作者: [Kusunoki, Soshi, Kato, Kiyoko, Takeda, Satoru]
通讯作者: Takeda, Satoru
22
    Development of new target therapy for endometrial cancer stem cells
    Contribution of the genomic diversity to the development and carcinogenesis of endometriosis
    • 批准号:
      22659302
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.96万
    • 财政年份:
      2010
    • 负责人:
      KATO Kiyoko
    • 依托单位:
    Analysis of endometrial cancer development
    • 批准号:
      17390452
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.71万
    • 财政年份:
      2005
    • 负责人:
      KATO Kiyoko
    • 依托单位:
    Analysis of molecular mechanism in endometrial cancer development.
    • 批准号:
      12557138
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.45万
    • 财政年份:
      2000
    • 负责人:
      KATO Kiyoko
    • 依托单位:
    海外基金