Contribution of the genomic diversity to the development and carcinogenesis of endometriosis
Contribution of the genomic diversity to the development and carcinogenesis of endometriosis
批准号:
22659302
负责人:
KATO Kiyoko
金额:
$1.96万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Tumorigenicity and the ER transcriptional activity were enhanced in endometrial stem cells harboring mutant KRAS compared with that in NSP harboring mutant KRAS gene. The ER/MDM2/p53/p21 pathway play an important role in the occurrence of endometrial cancer. The combination of homozygous GG genotype of MDM2 SNP309 and homozygous Arg/Arg genotype of TP53 codon72 was significantly associated the risk of endometrial cancer.
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子宮内膜幹細胞(side population細胞)の発癌機構への関与
子宫内膜干细胞(侧群细胞)参与致癌机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[加藤聖子, 他]
通讯作者:
他
子宮体癌幹細胞に対するヒストン脱アセチル化阻害剤の効果と作用機序
组蛋白去乙酰化抑制剂对子宫内膜癌干细胞的影响及作用机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[加藤聖子, 久原礼, 井上貴史, 久保山歩美, 楠木総司, 木村美葵, 須賀新, 寺尾泰久, 和氣徳夫, 竹田省]
通讯作者:
竹田省
A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.
通过对重复的单倍体基因组进行基因分型确定的明确的单倍型图谱发现了拷贝数变异事件中的主要单倍型偏好。
DOI:
--
发表时间:
2010
期刊:
Am.J.Hum.Genet. 86(6)
影响因子:
--
作者:
[Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.]
通讯作者:
Hayashi K.
DOI:
10.1111/j.1349-7006.2010.01543.x
发表时间:
2010-06-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Ohgami, Tatsuhiro, Kato, Kiyoko, Wake, Norio]
通讯作者:
Wake, Norio
子宮体癌発生機構におけるエストロゲンシグナルの関与
雌激素信号参与子宫内膜癌发生机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[馬場聖至, 多田訓子, 松野哲男, 梁朋飛, 張羅磊, 清水久芳, 歌田久司, 加藤聖子]
通讯作者:
加藤聖子
共 24 条
Identification of endometrial cancer stem cell markers
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批准号:24659736
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2012
-
负责人:KATO Kiyoko
-
依托单位:
Development of new target therapy for endometrial cancer stem cells
-
批准号:23390392
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.9万
-
财政年份:2011
-
负责人:KATO Kiyoko
-
依托单位:
Analysis of endometrial cancer development
-
批准号:17390452
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.71万
-
财政年份:2005
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负责人:KATO Kiyoko
-
依托单位:
Analysis of molecular mechanism in endometrial cancer development.
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批准号:12557138
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
-
负责人:KATO Kiyoko
-
依托单位:
Analysis of signal transaction associated with proliferation and progression in gynecologic cancer
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批准号:11671629
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
-
财政年份:1999
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负责人:KATO Kiyoko
-
依托单位:
Analysis of signal transduction associate with carcinogenesis and progression in endometrial and ovarian carcinoma.
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批准号:08671905
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:1996
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负责人:KATO Kiyoko
-
依托单位:
Role of Ras and Ras-relatd protein for carcinogenesis of endometrial
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批准号:05671379
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1993
-
负责人:KATO Kiyoko
-
依托单位:
海外基金