Regeneration of retinal neuron using Muller cells in the infarction area

使用梗塞区域的 Muller 细胞再生视网膜神经元

• 批准号: 24659759
• 负责人: MURATA Toshinori
• 金额: $ 2.41万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659759/
• 关键词: 網膜; 梗塞; 前駆細胞; ミュラー細胞; 糖尿病網膜症; 網膜神経線維; 神経線維前駆細胞; 糖尿病黄斑浮腫; 網膜虚血; グリア細胞; GFAP

To make infarction in the retina, we used two models.1) laser induced necrotic area. 2) Kimba mice, transgenic mice that overexpress vascular endothelial growth factor in the retina. We developed a method to detect these infarcted area with optical coherence tomography or fluorescein angiography. We attempted to establish a method to induce expression of neurobslastic markers such as Pax6 and nestin in regenerative Muller cells in the retinal infarction. The definite protocol has to be pursued in the further studies.

为了制造视网膜梗死，我们使用了两个模型。1)激光诱导坏死区。2) Kimba小鼠，视网膜过表达血管内皮生长因子的转基因小鼠。我们开发了一种方法来检测这些梗死区域的光学相干断层扫描或荧光素血管造影。我们试图建立一种方法，在视网膜梗死的再生Muller细胞中诱导Pax6和nestin等神经母细胞标志物的表达。在进一步的研究中，还需寻求明确的方案。

项目成果

Rag1 expression in RGCs is involved in programmed cell death

RGC 中的 Rag1 表达参与程序性细胞死亡

• 发表时间: 2013
• 作者: Takao Hirano;Takuma Hayashi;Toshinori Murata
• 通讯作者: Toshinori Murata

Effect of Laser Wavelength on Delivering Appropriate Laser Burns through the Opaque Lens Using a Pattern Scan Laser

激光波长对使用图案扫描激光器通过不透明透镜提供适当激光烧伤的影响

• 发表时间: 2014
• 期刊: Ophthalmic Res
• 影响因子: 2.1
• 作者: Hirano T;Iesato Y;Imai A;Toriyama Y;Kikushima W;Murata T
• 通讯作者: Murata T

Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients

• DOI: 10.1016/j.jdiacomp.2014.03.003
• 发表时间: 2014-09-01
• 期刊: JOURNAL OF DIABETES AND ITS COMPLICATIONS
• 影响因子: 3
• 作者: Hirano, Takao;Iesato, Yasuhiro;Murata, Toshinori
• 通讯作者: Murata, Toshinori