Development of new treatment modality for diabetic macular edema using knockout mice that show prominent retinal edema.

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Homozygote RAMP-2 knockout(KO) mice are fatal before delivery, but heterozygote RAMP-2 KO mice show largely normal development except for systemic edema. We found these mice have marked retinal edema. Diabetic retinal edema is a leading cause of legal blindness. There has been no animal model for retinal edema.(RAMP)-2 knockout mice are new and the only existing animal model of retinal edema. Using this model, we reported that insufficient formation of tight junction and disruption of Bruch' s membrane are potential causes of breakdown of blood-retinal barrier.