Role of interleukin-1α in CKD-associated cardiovascular complications (C09)

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We recently identified that lipoproteins from CKD patients enhance IL-1α release from monocytes. It is suggested that IL-1α represents a key alarmin, thereby initiating systemic inflammation. We hypothesize that IL-1α plays an important role in CKD-associated systemic inflammation contributing to CKD-related cardiovascular complications. This project aims to examine how alterations of lipoproteins in CKD modulate IL-1α production/secretion in a translational study design. Also, we will investigate the role of IL-1α in crucial processes underlying the development of CKD-associated CVD.