A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells
A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells
批准号:
25670615
负责人:
KITANAKA Chifumi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-04-01 至 2014-03-31
中文摘要
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英文摘要
Increased glucose metabolism often occurs in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism has an essential role in the maintenance of glioma stem cells. The results suggested that inhibition of an intracellular molecule presumed to be involved in glucose metabolism might affect the stemness of glioma stem cells, in support of the idea that glucose metabolism is involved in the maintenance of glioma stem cells.
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グリオーマ幹細胞
神经胶质瘤干细胞
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y, 北中千史]
通讯作者:
北中千史
治療への応用を目指したグリオーマ幹細胞研究 --アップデート --
胶质瘤干细胞研究旨在治疗应用--更新--
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kitanaka C, Sato A, Okada M, 北中千史, 北中千史, 佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 佐藤篤,岡田雅司,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史, 北中千史, 北中千史]
通讯作者:
北中千史
A549非小細胞肺癌細胞の腫瘍形成能維持におけるJNKの特異的な役割
JNK在维持A549非小细胞肺癌细胞致瘤潜力中的具体作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kitanaka C, Sato A, Okada M, 北中千史, 北中千史, 佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 佐藤篤,岡田雅司,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史]
通讯作者:
岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史
DOI:
10.3892/ijo.2013.2209
发表时间:
2014-02-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Okada, Masashi, Sato, Atsushi, Kitanaka, Chifumi]
通讯作者:
Kitanaka, Chifumi
レスベラトロールによるNanog-p53経路を介したグリオーマ幹細胞の制御
白藜芦醇通过 Nanog-p53 途径调节神经胶质瘤干细胞
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C, 佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正]
通讯作者:
佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正
共 12 条
Taking advantage of a pitfall in glioma cancer stem cell epigenetics to develop novel therapies directed to cancer stem cells
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批准号:16K15640
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
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负责人:KITANAKA Chifumi
-
依托单位:
An attempt to answer the cardinal question --- why do cancer cells have such a sweet tooth? --- through glioma stem cell research
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批准号:15K15522
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2015
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负责人:KITANAKA Chifumi
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依托单位:
An attempt to create an animal model for glioblastoma cure via proving the hypothesis that glucose metabolism serves as a rheostat to determine the cell fate of cancer stem cells
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批准号:26670635
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:KITANAKA Chifumi
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依托单位:
A systematic approach to achieve glioblastoma cure via targeting glioma stem cells
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批准号:24390338
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
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财政年份:2012
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负责人:KITANAKA Chifumi
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依托单位:
An attempt to pioneer a new research field through fusion of studies on cancer cell energy metabolism and glioma stem cells
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批准号:23659682
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:KITANAKA Chifumi
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依托单位:
Overcoming therapy resistance of glioma via elucidation of the mechanisms underlying glioma stem cell maintenance
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批准号:21390402
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2009
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负责人:KITANAKA Chifumi
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依托单位:
Identification of novel genes that determine cell's sensitivity to anticancer treatments/cell death in malignant tumors of neuronal origin
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批准号:18390389
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.64万
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财政年份:2006
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负责人:KITANAKA Chifumi
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依托单位:
Molecular mechanisms involved in non-apoptotic programmed cell death regulation
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批准号:14580708
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:KITANAKA Chifumi
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依托单位: