An attempt to pioneer a new research field through fusion of studies on cancer cell energy metabolism and glioma stem cells
An attempt to pioneer a new research field through fusion of studies on cancer cell energy metabolism and glioma stem cells
批准号:
23659682
负责人:
KITANAKA Chifumi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
In this project, we investigated the effect of a mitochondrial respiration-promoting agent on glioma stem cells with the intention to test the working hypothesis that inhibited mitochondrial respiration accompanied by increased aerobic glycolysis (Warburg effect), which has been frequently observed in malignant gliomas, contributes to the maintenance of glioma stem cells. Our results showed that promotion of mitochondrial respiration caused loss of stemness of glioma stem cells, suggesting that Warburg effect plays a significant role in the maintenance of glioma stem cells and that Warburg effect may be a promising target for cancer stem cell-directed therapy.
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グリオーマ幹細胞
神经胶质瘤干细胞
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y, 北中千史]
通讯作者:
北中千史
MEK 経路阻害によるMGMT 発現およびテモゾロミド感受性に関する検討
MEK通路抑制对MGMT表达及替莫唑胺敏感性的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Saito R, 他5名, 佐藤篤]
通讯作者:
佐藤篤
A549非小細胞肺癌細胞の腫瘍形成能維持におけるJNKの特異的な役割
JNK在维持A549非小细胞肺癌细胞致瘤潜力中的具体作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kitanaka C, Sato A, Okada M, 北中千史, 北中千史, 佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 佐藤篤,岡田雅司,成田善孝,渋井壮一郎,北中千史,嘉山孝正, 岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史]
通讯作者:
岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史
MEK inhibition enhances temozolomide sensitivity of glioma stem-like cells via MGMT down-regulation
MEK 抑制通过 MGMT 下调增强神经胶质瘤干细胞样细胞的替莫唑胺敏感性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sato A, Matsuda KI, Sunayama J, Sakurada K, Tachibana K, Tomiyama A, Kitanaka C, Kayama T]
通讯作者:
Kayama T
脳腫瘍のcell biology-グリオーマ幹細胞-
脑肿瘤的细胞生物学 - 神经胶质瘤干细胞 -
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Shichinohe H, Kuroda S, Sugiyama T, Ito M, Kawabori M, Nishio M, Takeda Y, Koike T, Houkin K, 北中千史]
通讯作者:
北中千史
共 32 条
Taking advantage of a pitfall in glioma cancer stem cell epigenetics to develop novel therapies directed to cancer stem cells
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批准号:16K15640
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
-
负责人:KITANAKA Chifumi
-
依托单位:
An attempt to answer the cardinal question --- why do cancer cells have such a sweet tooth? --- through glioma stem cell research
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批准号:15K15522
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2015
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负责人:KITANAKA Chifumi
-
依托单位:
An attempt to create an animal model for glioblastoma cure via proving the hypothesis that glucose metabolism serves as a rheostat to determine the cell fate of cancer stem cells
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批准号:26670635
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
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负责人:KITANAKA Chifumi
-
依托单位:
A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells
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批准号:25670615
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
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负责人:KITANAKA Chifumi
-
依托单位:
A systematic approach to achieve glioblastoma cure via targeting glioma stem cells
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批准号:24390338
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
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财政年份:2012
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负责人:KITANAKA Chifumi
-
依托单位:
Overcoming therapy resistance of glioma via elucidation of the mechanisms underlying glioma stem cell maintenance
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批准号:21390402
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2009
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负责人:KITANAKA Chifumi
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依托单位:
Identification of novel genes that determine cell's sensitivity to anticancer treatments/cell death in malignant tumors of neuronal origin
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批准号:18390389
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.64万
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财政年份:2006
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负责人:KITANAKA Chifumi
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依托单位:
Molecular mechanisms involved in non-apoptotic programmed cell death regulation
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批准号:14580708
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:KITANAKA Chifumi
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依托单位:
海外基金