Development and pathological characterization of genetically modified macaque monkey with eye disease.

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The structural and molecular characteristic of human eye is very unique to primate and different from other species. Development of animal model, which completely mimic the human eye diseases such as glaucoma, age-related macular degeneration and macular dystrophies has been difficult due to technical issues. In this research project we used the zinc finger nuclease (ZFN) technology to develop knockout or knockin macaque monkey. Developed monkeys will be maintained for pathological and visual function examination to understand the progression of the disease.