Exploration of seeds for development of a new drug targeting Bone-Vascular-Spleen axis

骨-血管-脾轴新药种子开发探索

• 批准号: 25670793
• 负责人: UDAGAWA Nobuyuki
• 金额: $ 2.41万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670793/
• 关键词: 破骨細胞; 骨芽細胞; マクロファージ; 脾臓; RANKL; M-CSF; IL-34; ミクログリア; 皮膚; 脳; ビタミンD; 単球; 血管

项目成果

Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.

用核因子 - κB配体（RANKL）结合肽的受体激活剂治疗的小鼠的皮质骨刺激骨形成，该肽具有破骨构成抑制活性。

• DOI: 10.1074/jbc.m112.426080
• 发表时间: 2013-02-22
• 期刊: The Journal of biological chemistry
• 作者: Furuya Y;Inagaki A;Khan M;Mori K;Penninger JM;Nakamura M;Udagawa N;Aoki K;Ohya K;Uchida K;Yasuda H
• 通讯作者: Yasuda H

Vitamin D endocrine system and osteoclasts.

• DOI: 10.1038/bonekey.2013.229
• 发表时间: 2014
• 期刊: BoneKEy reports
• 作者: Takahashi, Naoyuki;Udagawa, Nobuyuki;Udagawa, Naoyuki;Suda, Tatsuo
• 通讯作者: Suda, Tatsuo

Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.

• DOI: 10.1371/journal.pone.0085878
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamashita T;Uehara S;Udagawa N;Li F;Kadota S;Esumi H;Kobayashi Y;Takahashi N
• 通讯作者: Takahashi N

Encyclopedia of Human Body 3rd Edition

人体百科全书第三版

• 发表时间: 2015
• 作者: Takahashi;N.;Mizoguchi;T.;Nakamichi;Y.;Kobayashi;Y.;Nakamura;M.;Hofstetter;W.;Udagawa;N.
• 通讯作者: N.

The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts

• DOI: 10.1007/s00774-015-0683-1
• 发表时间: 2016-07
• 期刊: Journal of Bone and Mineral Metabolism
• 影响因子: 3.3
• 作者: Gnanasagar J. Thirukonda;Shunsuke Uehara;Takahiro Nakayama;T. Yamashita;Yukio Nakamura;T. Mizoguchi;N. Takahashi;K. Yagami;N. Udagawa;Yasuhiro Kobayashi