Small heat-shock molecular chaperone proteins and amyloid fibrils

小热休克分子伴侣蛋白和淀粉样原纤维

• 批准号: DP0665037
• 负责人: Em/Prof John Carver
• 金额: $ 19.19万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0665037
• 关键词: Small; heat; shock; molecular; chaperone

This proposal addresses the fundamental mechanisms of protein aggregation associated with debilitating age-related diseases, e.g. Alzheimer's, Parkinson's and cataract, and the prevention of aggregation via the action of a group of molecular chaperone proteins known as small heat-shock proteins. With the ageing population, the prevalence of these diseases will increase significantly over the next 20 years. Understanding and treating these diseases will therefore have significant long-term health benefits. Furthermore, the highly structured protein aggregates that form as hallmarks of many of these diseases have potential wide ranging applications in the emerging field of bionanotechnology, e.g. as nanowires and biofilms.

这一建议解决了与衰老相关疾病（如阿尔茨海默病、帕金森病和白内障）相关的蛋白质聚集的基本机制，以及通过一组被称为小热休克蛋白的分子伴侣蛋白的作用来预防聚集。随着人口老龄化，这些疾病的发病率将在今后20年显著增加。因此，了解和治疗这些疾病将具有重大的长期健康益处。此外，作为许多这些疾病的标志而形成的高度结构的蛋白质聚集体在新兴的生物纳米技术领域具有潜在的广泛应用，例如纳米线和生物膜。