Astrocyte- and dendritic cell-specific function of the deubiquitinating enzyme Cezanne (OTUD7B) in experimental cerebral malaria (A30*)

A30 N将评估去泛素化酶（DUB）OTUD 7 B在实验性脑型疟疾（ECM）过程中的星形胶质细胞和树突状细胞（DC）特异性功能。该项目旨在确定（1）OTUD 7 B在星形胶质细胞和DC中的相互作用伴侣，（2）泛素修饰的类型和（3）OTUD 7 B功能所需的结构域。A30 N将进一步帮助理解CNS感染临床相关模型中的信号转导和细胞间免疫细胞通讯。A30 N将与其他在NF-κ B B信号传导（A04）、DUBs（A05）、CNS感染（A25、A28 N）、星形胶质细胞生物学（A29 N）和双光子显微镜（B31 N、Z 01）方面具有专长的CRC 854项目合作。

A30N will assess astrocyte- and dendritic cell (DC)-specific function of the deubiquitinating enzyme (DUB) OTUD7B in the course of experimental cerebral malaria (ECM). The project aims to identify (1) the interaction partners of OTUD7B in astrocytes and DCs, (2) the type of ubiquitin modification and (3) the structural domains necessary for OTUD7B function. A30N will further aid the understanding of signal transduction and intercellular immune cell communication in a clinically relevant model of CNS infection. A30N will cooperate with other CRC854 projects having expertise in NF-B signaling (A04), DUBs (A05), CNS infection (A25, A28N), astrocyte biology (A29N) and 2-photon microscopy (B31N, Z01).