权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of Computer-Aided Supporting System for Angiotensin II-Induced Hypertension Cancer Chemotherapy

血管紧张素II诱导高血压癌症化疗计算机辅助支持系统的开发

基本信息

批准号：
01870102
负责人：
SUZUKI Maroh
金额：
$ 6.34万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

The purpose of the present study is the realization of a supporting system for induced hypertension chemotherapy (IHC) which is effective but some difficult to do.(1) The quantitative researches about formation of angioarchitecture and physiological variation of blood flow in rat subcutaneous tumors have shown the mechanism and the efficacy of IHC. The other new drug delivery system by which blood pressure is pharmacologically lowered immediately after IHC to the stoppage of perfusion in only tumor tissues, named "flooding-the-castle chemotherapy" (FCC), has been examined from many aspects.(2) Fuzzy-logic software for strict and steady control of blood pressure, which is essential for IHC and FCC, was developed. The use of the program and 32-bit microcomputer has made the automatic blood pressure control for IHC and FCC possible in animal experiments.(3) The effectiveness of manual (i. e. without a supporting system) IHC has been proved in many clinical aspects (randomized-controlled study with advanced gastric carcinoma, preoperative chemotherapy for gastric carcinoma, therapy of lymphatic metastasis from various primary tumors, and ambulatory therapy for advanced cancer). These studies have proved the significance and the priority of the present system.(4) Now, the improvement of the system is tried with animal experiments. However it is possible to use the present system for clinical IHC under the control of an expert doctor at IHC.(5) Important problem for clinical applications of the system is the realization of the prompt, accurate, and less-invasive real-time measurement of mean arterial blood pressure and the high quality infusion pomp which can change the infusion rate instantly.

本研究的目的是实现一个有效但难以实现的诱导性高血压化疗（IHC）支持系统。(1)对大鼠皮下肿瘤血管构筑形成和血流生理变化的定量研究，揭示了免疫组化的作用机制和疗效。另一种新的药物输送系统，即在IHC后立即降低血压，仅在肿瘤组织中停止灌注，称为“城堡化疗”（FCC），已从多个方面进行了研究。(2)开发了用于IHC和FCC所必需的严格和稳定的血压控制的模糊逻辑软件。该程序和32位微型计算机的使用使动物实验中IHC和FCC的自动血压控制成为可能。(3)手册的有效性（一）e.在没有支持系统的情况下）IHC已经在许多临床方面（进展期胃癌的随机对照研究、胃癌的术前化疗、各种原发性肿瘤的淋巴转移的治疗以及进展期癌症的门诊治疗）得到证实。这些研究证明了本系统的重要性和优越性。(4)目前，该系统的改进尝试通过动物实验。然而，可以在IHC的专家医生的控制下将本系统用于临床IHC。(5)实现快速、准确、微创的平均动脉压实时测量和高质量的输液泵能即时改变输液速度是该系统临床应用的重要问题。