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Synthesis of magnetic glass-ceramic for hyperthermia treatment of cancer

Synthesis of magnetic glass-ceramic for hyperthermia treatment of cancer
用于癌症热疗的磁性微晶玻璃的合成
批准号:
01890008
负责人:
KOKUBO Tadashi
金额:
$6.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research
财政年份:
1989
资助国家:
日本
项目状态:
已结题
起止时间:
1989 至 1991

项目摘要

项目成果

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中文摘要
翻译
Bioactive and ferromagnetic glass-ceramic is believed to be useful as thermoseeds for hyperthermiatreatment of cancer,自bonds to self well as to the bone to be fixed when it is implanted around tumor,那群人是受影响的地方up to 43゚C effective for cancer treatment by magnetichysteresis loss, when subjected to an alternating magnetic field. In the present studysynthesis of such bioactive and ferromagnetic glass-ceramic and application of it to the thermoseedswere investigated.A glass of the composition fe_2_340, CaO . sio_260, b_2_33,p_2_53 wt ratio precipitated magnetite 200 nm in size and 36wt % in amount in a matrix of CaO,sio_2 -based glassy phase and flu -wollastonite(CaO sio_2)when heated up to 1050゚C. The obtained glass-ceramics showed a ferromagnetism with saturationmagnetization of 32 emu/g and coercive force of 120 Oe as as well as bioactivity. About 5g of theglass-ceramic 0.1 to 1.0 mm in size filled into a marrow of rabbit tibia effectively heated outersurface of the tibia up to 43゚C,within 5 min after an alternating magnetic field of 100khz up to 300 Oe was applied. When a pin 3mm in diameter and 5cm in length of the glass-ceramic was inserted into amarrow of rabbit tibia towhich tumor had been transplanted, and subjected to the alternating magnetic field for 50 min,这是确认后3周,所有的cancer cells in the marrow,被完全killed by thehyperthermia treatment using the glass-ceramic。
英文摘要
Bioactive and ferromagnetic glass-ceramic is believed to be useful as thermoseeds for hyperthermia treatment of cancer, since it bonds to itself as well as to the bone to be fixed when it is implanted around tumor, and then the tumor is heated locally up to 43 ゚C effective for cancer treatment by magnetic hysteresis loss, when subjected to an alternating magnetic field. In the present study, synthesis of such bioactive and ferromagnetic glass-ceramic and application of it to the thermoseeds were investigated.A glass of the composition Fe_2O_3 40, CaO・SiO_2 60, B_2O_3 3, P_2O_5 3 wt ratio precipitated magnetite 200 nm in size and 36 wt% in amount in a matrix of CaO, Sio_2-based glassy phase and fl-wollastonite(CaO・SiO_2), when heated up to 1050 ゚C. The obtained glass-ceramics showed a ferromagnetism with saturation magnetization of 32 emu/g and coercive force of 120 Oe as well as bioactivity. About 5 g of the glass-ceramic 0.1 to 1.0 mm in size filled into a marrow of rabbit tibia effectively heated outer surface of the tibia up to 43 ゚C, within 5 min after an alternating magnetic field of 100 kHz up to 300 Oe was applied. When a pin 3 mm in diameter and 5 cm in length of the glass-ceramic was inserted into amarrow of rabbit tibia to which tumor had been transplanted, and subjected to the alternating magnetic field for 50 min, it was confirmed after 3 weeks that all the cancer cells in the marrow were completely killed by the hyperthermia treatment using the glass-ceramic.
期刊论文(78)
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科研奖励(0)
会议论文
Y. Ebisawa: "Bioactivity of CaO・SiO_2-based glasses : in vitro evaluation" Materials in Medicine. 1. 239-244 (1990)
Y. Ebisawa:“CaO・SiO_2 基玻璃的生物活性:体外评价”Materials in Medicine,1. 239-244 (1990)。
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通讯作者:
Yukihiro Ebisawa: "Crystallization of (FeO,Fe_2O_3)ーCaOーSiO_2 glasses and Magnetic Properties of their Crystallized Products" Seramikkusu Ronbunshi. 99. 7-13 (1991)
Yukihiro Ebisawa:“(FeO,Fe_2O_3)-CaO-SiO_2 玻璃的结晶及其结晶产物的磁性” Seramikkusu Ronbunshi。 99. 7-13 (1991)
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通讯作者:
T.Kokubo: "Bioactive glass-ceramics: properties and applications" Biomaterials. 12. 155-163 (1991)
T.Kokubo:“生物活性玻璃陶瓷:特性和应用”生物材料。
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发表时间:
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35
    APATITE-FORMING ABILITY OF ORGANIC POLYMERS CONTAINING CARBOXY GROUP
    • 批准号:
      13680934
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.62万
    • 财政年份:
      2001
    • 负责人:
      KOKUBO Tadashi
    • 依托单位:
    Mechanism of Apatite Nucleation in Biomimetic Process
    • 批准号:
      11490020
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $8.7万
    • 财政年份:
      1999
    • 负责人:
      KOKUBO Tadashi
    • 依托单位:
    Preparation of Bioactive Metals by Chemical Treatments
    • 批准号:
      07559008
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $12.16万
    • 财政年份:
      1995
    • 负责人:
      KOKUBO Tadashi
    • 依托单位:
    Preparation of Inorganic-Organic Composites by Biomimetic Process and their Applications for Biomedial Materials
    • 批准号:
      05405005
    • 项目类别:
      Grant-in-Aid for General Scientific Research (A)
    • 资助金额:
      $15.36万
    • 财政年份:
      1993
    • 负责人:
      KOKUBO Tadashi
    • 依托单位:
    海外基金