Synthesis of magnetic glass-ceramic for hyperthermia treatment of cancer
Synthesis of magnetic glass-ceramic for hyperthermia treatment of cancer
批准号:
01890008
负责人:
KOKUBO Tadashi
金额:
$6.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research
财政年份:
1989
资助国家:
日本
项目状态:
已结题
起止时间:
1989 至 1991
中文摘要
生物活性和铁磁玻璃--陶瓷被认为是有用的,因为它本身是通过良好的方式来修复癌症的超热治疗,当它在肿瘤周围植入时,然后肿瘤在局部加热到43 ℃ C对癌症治疗的效果,当磁性歇斯底里丢失时,被拒绝替代磁场。在目前的研究中,这种生物活性和铁磁玻璃的合成--陶瓷及其在热片基质中的应用--组合物的玻璃Fe_2O_340、CaO·SiO_260、B_2O_33、P_2O_5 3 wt比率高出磁铁在尺寸上200 nm,在CaO、Sio_2-基玻璃相位和fl-wollastonite的体积上占36 wt%(CaO·SiO_2),当升温至1050 ℃时。获得的玻璃陶瓷展示了具有32 μ g饱和磁化和120 μ e的协同力的铁磁作用,如生物活性良好。大约5克玻璃陶瓷0.1至1.0毫米,在尺寸上填充了一个兔子蒂比亚的马蹄铁的外表面,有效加热到43 ° C,在100千赫的交替磁场下5分钟后,应用到300 Oe。当直径为3毫米的别针和5厘米的玻璃陶瓷被插入到被移植的兔子tibia,并被提交到50分钟的替代磁场中,3周后,它被确认为所有的癌症细胞都完全被玻璃陶瓷的高温治疗杀死了。
英文摘要
Bioactive and ferromagnetic glass-ceramic is believed to be useful as thermoseeds for hyperthermia treatment of cancer, since it bonds to itself as well as to the bone to be fixed when it is implanted around tumor, and then the tumor is heated locally up to 43 ゚C effective for cancer treatment by magnetic hysteresis loss, when subjected to an alternating magnetic field. In the present study, synthesis of such bioactive and ferromagnetic glass-ceramic and application of it to the thermoseeds were investigated.A glass of the composition Fe_2O_3 40, CaO・SiO_2 60, B_2O_3 3, P_2O_5 3 wt ratio precipitated magnetite 200 nm in size and 36 wt% in amount in a matrix of CaO, Sio_2-based glassy phase and fl-wollastonite(CaO・SiO_2), when heated up to 1050 ゚C. The obtained glass-ceramics showed a ferromagnetism with saturation magnetization of 32 emu/g and coercive force of 120 Oe as well as bioactivity. About 5 g of the glass-ceramic 0.1 to 1.0 mm in size filled into a marrow of rabbit tibia effectively heated outer surface of the tibia up to 43 ゚C, within 5 min after an alternating magnetic field of 100 kHz up to 300 Oe was applied. When a pin 3 mm in diameter and 5 cm in length of the glass-ceramic was inserted into amarrow of rabbit tibia to which tumor had been transplanted, and subjected to the alternating magnetic field for 50 min, it was confirmed after 3 weeks that all the cancer cells in the marrow were completely killed by the hyperthermia treatment using the glass-ceramic.
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Y. Ebisawa: "Bioactivity of CaO・SiO_2-based glasses : in vitro evaluation" Materials in Medicine. 1. 239-244 (1990)
Y. Ebisawa:“CaO・SiO_2 基玻璃的生物活性:体外评价”Materials in Medicine,1. 239-244 (1990)。
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通讯作者:
Yukihiro Ebisawa: "Crystallization of (FeO,Fe_2O_3)ーCaOーSiO_2 glasses and Magnetic Properties of their Crystallized Products" Seramikkusu Ronbunshi. 99. 7-13 (1991)
Yukihiro Ebisawa:“(FeO,Fe_2O_3)-CaO-SiO_2 玻璃的结晶及其结晶产物的磁性” Seramikkusu Ronbunshi。 99. 7-13 (1991)
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T. Kokubo: "Recent Progress in Glass-Based Materials for Biomedical Applications" J. Ceram. Soc. Japan. 99. 965-973 (1991)
T. Kokubo:“生物医学应用玻璃基材料的最新进展”J. Ceram。
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T.Kokubo: "Bioactive glass-ceramics: properties and applications" Biomaterials. 12. 155-163 (1991)
T.Kokubo:“生物活性玻璃陶瓷:特性和应用”生物材料。
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通讯作者:
Koichiro Ohura: "Bioactivity of CaO・SiO_2 Glasses added with Various Ions" Materials in Medicine.
Koichiro Ohura:“添加各种离子的CaO·SiO_2玻璃的生物活性”医学材料。
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共 35 条
APATITE-FORMING ABILITY OF ORGANIC POLYMERS CONTAINING CARBOXY GROUP
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批准号:13680934
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
-
财政年份:2001
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负责人:KOKUBO Tadashi
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依托单位:
Mechanism of Apatite Nucleation in Biomimetic Process
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批准号:11490020
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.7万
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财政年份:1999
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负责人:KOKUBO Tadashi
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依托单位:
Preparation of Bioactive Metals by Chemical Treatments
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批准号:07559008
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.16万
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财政年份:1995
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负责人:KOKUBO Tadashi
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依托单位:
Preparation of Inorganic-Organic Composites by Biomimetic Process and their Applications for Biomedial Materials
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批准号:05405005
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$15.36万
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财政年份:1993
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负责人:KOKUBO Tadashi
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依托单位:
Properties of Glass Implanted with Phosphorus for Radiotherapy
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批准号:04559005
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$8.9万
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财政年份:1992
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负责人:KOKUBO Tadashi
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依托单位:
Hardening and reaction mechanism of bioactive cement based on glass
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批准号:03455015
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.67万
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财政年份:1991
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负责人:KOKUBO Tadashi
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依托单位:
Fundamental Study of Bioactivity of Inorganic Materials
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批准号:01430014
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$12.48万
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财政年份:1989
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负责人:KOKUBO Tadashi
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依托单位:
Surface Structure of Bioactive Ceramics
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批准号:61470072
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.29万
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财政年份:1986
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负责人:KOKUBO Tadashi
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依托单位:
海外基金