Synthesis of magnetic glass-ceramic for hyperthermia treatment of cancer

生物活性和铁磁玻璃--陶瓷被认为是有用的，因为它本身是通过良好的方式来修复癌症的超热治疗，当它在肿瘤周围植入时，然后肿瘤在局部加热到43 ℃ C对癌症治疗的效果，当磁性歇斯底里丢失时，被拒绝替代磁场。在目前的研究中，这种生物活性和铁磁玻璃的合成--陶瓷及其在热片基质中的应用--组合物的玻璃Fe_2O_340、CaO·SiO_260、B_2O_33、P_2O_5 3 wt比率高出磁铁在尺寸上200 nm，在CaO、Sio_2-基玻璃相位和fl-wollastonite的体积上占36 wt%（CaO·SiO_2），当升温至1050 ℃时。获得的玻璃陶瓷展示了具有32 μ g饱和磁化和120 μ e的协同力的铁磁作用，如生物活性良好。大约5克玻璃陶瓷0.1至1.0毫米，在尺寸上填充了一个兔子蒂比亚的马蹄铁的外表面，有效加热到43 ° C，在100千赫的交替磁场下5分钟后，应用到300 Oe。当直径为3毫米的别针和5厘米的玻璃陶瓷被插入到被移植的兔子tibia，并被提交到50分钟的替代磁场中，3周后，它被确认为所有的癌症细胞都完全被玻璃陶瓷的高温治疗杀死了。

Bioactive and ferromagnetic glass-ceramic is believed to be useful as thermoseeds for hyperthermia treatment of cancer, since it bonds to itself as well as to the bone to be fixed when it is implanted around tumor, and then the tumor is heated locally up to 43 ﾟC effective for cancer treatment by magnetic hysteresis loss, when subjected to an alternating magnetic field. In the present study, synthesis of such bioactive and ferromagnetic glass-ceramic and application of it to the thermoseeds were investigated.A glass of the composition Fe_2O_3 40, CaO・SiO_2 60, B_2O_3 3, P_2O_5 3 wt ratio precipitated magnetite 200 nm in size and 36 wt% in amount in a matrix of CaO, Sio_2-based glassy phase and fl-wollastonite(CaO・SiO_2), when heated up to 1050 ﾟC. The obtained glass-ceramics showed a ferromagnetism with saturation magnetization of 32 emu/g and coercive force of 120 Oe as well as bioactivity. About 5 g of the glass-ceramic 0.1 to 1.0 mm in size filled into a marrow of rabbit tibia effectively heated outer surface of the tibia up to 43 ﾟC, within 5 min after an alternating magnetic field of 100 kHz up to 300 Oe was applied. When a pin 3 mm in diameter and 5 cm in length of the glass-ceramic was inserted into amarrow of rabbit tibia to which tumor had been transplanted, and subjected to the alternating magnetic field for 50 min, it was confirmed after 3 weeks that all the cancer cells in the marrow were completely killed by the hyperthermia treatment using the glass-ceramic.