Properties of Glass Implanted with Phosphorus for Radiotherapy

放射治疗用掺磷玻璃的特性

• 批准号: 04559005
• 负责人: KOKUBO Tadashi
• 金额: $ 8.9万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04559005/
• 关键词: Radiotherapy; Ion implantation; Phosphorus; Silica glass; Cancer; Chemical durability; Rutherford backscattering; FT-IR spectra; 放射線治療; 高周波誘導結合プラズマ発光分析; フーリエ変換赤外反射分光

Highly pure silica glass implanted with phosphorus ion at 30keV by 5*10^<16>cm^<-2> dissolved almost all the phosphorus into the pure water at 95ﾟC during 7days. When this glass was heated at 400ﾟC in H_2 atmosphere and then heated at 900ﾟC in O_2 atmosphere, phosphorus in the glass became insoluble into the water. This suggests that phosphorus colloid grew by the heat treatment at 400ﾟC and that colloids were encapsulated in a thin SiO_2-P_2O_5 glass layr by the heat treatment at 900ﾟC.When the silica glass was implanted with nitrogen ion as well as phosphorus ion, and then subjected to the same heat treatment, highly phosphorus-containing silica glass with high chemical durability was obtained, since the evaporation of phosphorus on the heat treatment was suppressed by formation of silicon oxynitride. When the phosphorus ion was implanted to the silica glass at 50keV by 5*10^<16>cm^<-2>, it showed the maximum concentration at about 50nm depth and did not distribute up to the glass surface. As a result, this glass did not dissolve the phosphorus into the water in spite of the surface structural damage caused by the ion implantation. Moreover, the silica glass implanted with phosphorus ion at 200keV did not dissolve phosphorus even if a large dose of phosphorus, 1*10^<18>cm^<-2>, was implanted. It is expected that the glass obtained by the present method is useful for deep cancer treatments.

在30keV下注入磷离子的高纯石英玻璃5*10^<16>cm^<-2>在7天内将几乎所有的磷溶解到95℃的纯水中。当将该玻璃在H_2气氛中加热至400℃，然后在O_2气氛中加热至900℃时，玻璃中的磷变得不溶于水。这表明，磷胶体通过400℃的热处理而生长，并且通过900℃的热处理，胶体被封装在薄的SiO_2-P_2O_5玻璃层中。当在石英玻璃中同时注入氮离子和磷离子，然后进行相同的热处理时，可以获得具有高化学耐久性的高磷含量石英玻璃。 热处理时磷的蒸发通过形成氮氧化硅而受到抑制。当磷离子以50keV以5×10^16cm^-2注入到石英玻璃时，其在约50nm深度处显示出最大浓度并且没有分布到玻璃表面。结果，尽管离子注入造成了表面结构损坏，但这种玻璃并未将磷溶解到水中。而且，即使注入大剂量的磷(1×10^18cm^-2)，在200keV下注入磷离子的石英玻璃也不溶解磷。预计通过本方法获得的玻璃可用于深部癌症治疗。

项目成果

M.Kawashita: ""Preparation of Glass Implanted with Phosphorus and Nitrogen Ions for Radiotherapy"" J.Mater.Sci. : Medicine. (submitted).

M.Kawashita：“用于放射治疗的植入磷和氮离子的玻璃的制备”J.Mater.Sci。

M. Kawashita: "Prepartion of Glasses for Radiotherapy by Ion Implantation" Rad. Phys. Chem. (印刷中). (1995)

M. Kawashita：“离子注入放射治疗眼镜的制备”，Rad Phys（正在出版）。

T.Yao: ""Applications of Ion Implantation to Glasses for Biomedical Uses"" New Glass. 8. 91-95 (1993)

T.Yao：“离子注入在生物医学用途玻璃中的应用”新型玻璃。

八尾 健: "生体材料としてのガラスへのイオン注入の応用" NEW GLASS. 8. (1993)

Ken Yao：“离子注入作为生物材料在玻璃中的应用”NEW GLASS 8。（1993）

T.Yao: "Application of Ion Implantation in a Glass for Radiotherapy" Trans.Mat.Res.Soc.Jpn.17. 507-510 (1994)

T.Yao：“离子注入在放射治疗玻璃中的应用”Trans.Mat.Res.Soc.Jpn.17。