APATITE-FORMING ABILITY OF ORGANIC POLYMERS CONTAINING CARBOXY GROUP

含羧基有机聚合物的磷灰石形成能力

• 批准号: 13680934
• 负责人: KOKUBO Tadashi
• 金额: $ 2.62万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680934/
• 关键词: CARBOXY GROUP; APATITE; SIMULATED BODY FLUID; CHITIN; ALGINATE; GELLAN GUM; FIBERS; 3D-COMPOSITE; 三次元構造; 複合体; カードラン

Carboxymethylated chitin and gellan gum, both of which contain carboxy groups, formed an apatite on their surfaces in SBF, only after Ca(OH)_2 solution treatment. Cardlan gels containing no carboxy group did not form the apatite even after the Ca(OH)_2 treatment. Calcium alginate fibers were prepared by extruding sodium alginate solution into calcium chloride solution through a nozzle. Chitin fibers constituting a nonwoven fabric were carboxymethylated. Both of the fibers formed the apatite on their surfaces in SBF, after the Ca(OH)_2 treatment. The calcium ion released from the fibers treated with Ca(OH)_2 solution might form carboxy groups effective for the apatite nucleation on the surface of the fibers and accelerate the apatite nucleation by increasing ionic activity product of the apatite in SBF. The apatiteorganic fiber composite prepared by the present method is expected to be useful as a flexible bioactive b-one repairing material

含羧基的羧甲基甲壳素和结冷胶在模拟体液中，经Ca（OH）_2溶液处理后，表面才形成磷灰石。不含羧基的Cardlan凝胶经Ca（OH）_2处理后也不能形成磷灰石。通过喷嘴将海藻酸钠溶液挤出到氯化钙溶液中制备海藻酸钙纤维。将构成非织造织物的甲壳素纤维羧甲基化。经Ca（OH）_2处理后，两种纤维在模拟体液中均形成了磷灰石。Ca（OH）_2溶液处理纤维后释放出的钙离子可在纤维表面形成有利于磷灰石成核的羧基，通过增加磷灰石在模拟体液中的离子活度积，加速磷灰石成核。本方法制备的磷灰石/有机纤维复合材料有望作为一种柔性生物活性骨修复材料

项目成果

M. KAWASHITA: "APATITE-FORMING ABILITY OF CARBOXYL GROUP-CONTAINING POLYMER GELS IN A SIMULATED BODY FLUID"BIOMATERIALS. 24. 2177-2184 (2003)

M. KAWASHITA：“模拟体液中含羧基聚合物凝胶的磷灰石形成能力”生物材料。

T. KOKUBO: "HANDBOOK OF ADVANCED CERAMIC SCIENCE, MATERIALS, APPLICATIONS AND PROCESSING"ACADEMIC PRESS. IN PRESS. (2003)

T. KOKUBO：《高级陶瓷科学、材料、应用和加工手册》学术出版社。

T.Kokubo: "Ceramics for Biomedical Applications"Encyclopedia of Physical Science & Technology. 2. 615-619 (2002)

T.Kokubo：“生物医学应用陶瓷”物理科学百科全书

T.Kokubo: "Novel bioactive materials with different mechanical properties"Biomaterials. 24. 2161-2175 (2003)

T.Kokubo：“具有不同机械性能的新型生物活性材料”生物材料。

M.Kawashita: "Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid"Biomaterials. 24. 2477-2484 (2003)

M.Kawashita：“模拟体液中含羧基聚合物凝胶的磷灰石形成能力”生物材料。