APATITE-FORMING ABILITY OF ORGANIC POLYMERS CONTAINING CARBOXY GROUP

在SBF中，均含有羧基的羧甲基甲壳素和结冷胶只有在Ca(OH)2溶液处理后才在其表面形成磷灰石。不含羧基的Cardlan凝胶即使在氢氧化钙处理后也不能形成磷灰石。通过喷嘴将海藻酸钠溶液挤出到氯化钙溶液中，制得了海藻酸钙纤维。对构成非织造布的甲壳素纤维进行了羧甲基处理。经氢氧化钙处理后，两种纤维在SBF中的表面都形成了磷灰石。经Ca(OH)2溶液处理的纤维中释放出的钙离子可在纤维表面形成有利于磷灰石成核的羧基，并通过增加磷灰石在SBF中的离子活度积来加速其成核。该方法制备的磷灰石-有机纤维复合材料有望成为一种具有生物活性的柔性b-one修复材料。

Carboxymethylated chitin and gellan gum, both of which contain carboxy groups, formed an apatite on their surfaces in SBF, only after Ca(OH)_2 solution treatment. Cardlan gels containing no carboxy group did not form the apatite even after the Ca(OH)_2 treatment. Calcium alginate fibers were prepared by extruding sodium alginate solution into calcium chloride solution through a nozzle. Chitin fibers constituting a nonwoven fabric were carboxymethylated. Both of the fibers formed the apatite on their surfaces in SBF, after the Ca(OH)_2 treatment. The calcium ion released from the fibers treated with Ca(OH)_2 solution might form carboxy groups effective for the apatite nucleation on the surface of the fibers and accelerate the apatite nucleation by increasing ionic activity product of the apatite in SBF. The apatiteorganic fiber composite prepared by the present method is expected to be useful as a flexible bioactive b-one repairing material