The regulation of osteocyte function and mechanosignaling via light stimulus

通过光刺激调节骨细胞功能和机械信号传导

• 批准号: 15K15558
• 负责人: NOTOMI Takuya
• 金额: $ 2.33万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K15558/
• 关键词: 骨代謝; 骨細胞; 光遺伝学; 力学的刺激; 細胞膜電位; 光操作

项目成果

Zinc-induced effects on osteoclastogenesis involve activation of hyperpolarization-activated cyclic nucleotide modulated channels via changes in membrane potential

锌诱导的破骨细胞生成作用涉及通过膜电位变化激活超极化激活的环核苷酸调节通道

• DOI: 10.1002/jbmr.2507
• 发表时间: 2015
• 期刊: J Bone Miner Res
• 影响因子: 6.2
• 作者: Notomi T;Kuno M;Ohura K;Noda M and Skerry TM
• 通讯作者: Noda M and Skerry TM

Morphological and dynamic analysis of migration linked to FUCCI-indicated cell cycle under the influence of PTH and mechanical flow signals

在 PTH 和机械流信号的影响下，与 FUCCI 指示的细胞周期相关的迁移的形态学和动态分析

• 发表时间: 2015
• 作者: Jumpei Shirakawa;Yoichi Ezura;Shuichi Moriya;Makiri Kawasaki;Takayuki Yamada;Takuya Notomi;Tadayoshi Hayata;Atsushi Miyawaki;Ken Omura;Masaki Noda
• 通讯作者: Masaki Noda

Nck influences preosteoblastic/osteoblastic migration and bone mass

• DOI: 10.1073/pnas.1518253112
• 发表时间: 2015-11
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Smriti Aryal A.C;K. Miyai;Y. Izu;T. Hayata;T. Notomi;M. Noda;Y. Ezura

Changes in membrane potential regulates RANKL intracellular transport via voltage-gated calcium channels in osteoblasts

成骨细胞中膜电位的变化通过电压门控钙通道调节 RANKL 细胞内转运

• 发表时间: 2016
• 作者: Takuya Notomi;Miyuki Kuno;Akiko Hiyama;Yoichi Ezura;Kiyoshi Ohura;Masaki Noda
• 通讯作者: Masaki Noda

TGF-beta impairs cilia morphology via suppression of Ift88 expression in chondrocytic ATDC5 cells

TGF-β 通过抑制软骨细胞 ATDC5 细胞中的 Ift88 表达来损害纤毛形态

• 发表时间: 2015
• 作者: Makiri Kawasaki;Tadayoshi Hayata;Tetsuya Nakamoto;Takuya Notomi;Shiichi Moriya;Takayuki Yamada;Yayoi Izu;Yoichi Ezura;Masaki Noda
• 通讯作者: Masaki Noda