Investigation into the mechanism of mechano-transduction via neurotransmitter receptors and ion channels

骨骼疾病是老龄化社会的一个严重问题，其治疗是维持生活质量的必要手段。为了预防骨病的发生，我们对骨离子通道和膜电位的作用进行了研究。为了研究其通过离子通道和受体的信号传导机制，我们用光敏离子通道和泵检测了骨细胞的功能。将光门控离子通道和泵导入骨细胞，研究膜电位对骨细胞的作用。此外，基于他们的结果，我们确定了与骨重建相关的新的离子通道。综上所述，我们的研究结果表明，膜电位调节骨细胞功能，与骨重建相关的新型离子通道对破骨细胞功能具有重要作用。

Bone diseases are serious problem in an aged society and their treatment is necessary for maintaining QOL. To prevent bone diseases, we have done the study of effects of ion channels and membrane potential in bone. To investigate the signaling mechanism via ion channel and receptor, we examined the function of bone cells by light-sensitive ion channel and pump. The light-gated ion channels and pump were transfected into bone cells and then the role of membrane potential on those cells were investigated. Further, based on their results, we identified bone remodeling-related novel ion channels. In summary, our results indicate that membrane potential regulate bone cell function and bone remodeling-related novel ion channels are important for osteoclastic functions.