Light-induced regulation of the function of osteocyte and bone remodelling

光诱导调节骨细胞功能和骨重塑

• 批准号: 25670638
• 负责人: NOTOMI Takuya
• 金额: $ 2.41万
• 依托单位: Osaka Dental University (2014)Tokyo Medical and Dental University (2013)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670638/
• 关键词: 骨代謝; 力学的刺激

项目成果

Tob1, a BMP repressor, is activated by parathyroid hormone in osteoblasts in vitro and in vivo and reciprocally regulates PTH signaling

Tob1 是一种 BMP 阻遏蛋白，在体外和体内被成骨细胞中的甲状旁腺激素激活，并相互调节 PTH 信号传导

• 作者: Shuichi Moriya;Tadayoshi Hayata;Jumpei Shirakawa;Makiri Kawasaki;Takuya Notomi;Yoichi Ezura;Kazuo Kaneko;Masaki Noda
• 通讯作者: Masaki Noda

PTH Additively Enhances The Mechanical Stress-induced Proliferation of Calvarial Osteoblasts

PTH 进一步增强机械应力诱导的颅骨成骨细胞增殖

• 作者: Jumpei Shirakawa;Yoichi Ezura;Makiri Kawasaki;Takayuki Yamada;Shuichi Moriya;Takuya Notomi;Tadayoshi Hayata;Ken Omura;Masaki Noda
• 通讯作者: Masaki Noda

β2Adrenergic Receptor agonist suppresses BMP-induced osteoblastic differentiation in MC3T3E-1 cells while epinephrine modulates it differently

β2肾上腺素能受体激动剂抑制 BMP 诱导的 MC3T3E-1 细胞中的成骨细胞分化，而肾上腺素对其进行不同的调节

• 作者: Takayuki Yamada;Tadayoshi Hayata;Takuya Notomi;Yoichi Ezura;Kiyoshi Harada;Masaki Noda
• 通讯作者: Masaki Noda

β2 Adrenergic receptor activation suppresses BMP-induced alkaline phosphatase expression in osteoblast-like MC3T3E1 cells.

β2 肾上腺素受体激活抑制成骨细胞样 MC3T3E1 细胞中 BMP 诱导的碱性磷酸酶表达。

• DOI: 10.1002/jcb.25071
• 发表时间: 2015
• 期刊: Journal of Cellular Biochemistry
• 影响因子: 4
• 作者: Yamada;T.;Ezura;Y.;Hayata;T.;Moriya;S.;Shirakawa;J.;Notomi;T.;Arayal;S.;Kawasaki;M.;Izu;Y.;Harada;K.;and Noda;M.
• 通讯作者: M.

Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.

• DOI: 10.1016/j.bone.2014.05.002
• 发表时间: 2014-08
• 期刊: Bone
• 影响因子: 4.1
• 作者: T. Notomi;Ikuaki Karasaki;Y. Okazaki;N. Okimoto;Yushi Kato;K. Ohura;M. Noda;Toshitaka Nakamura;Masashige Suzuki