A Versatile Strategy for Developing Long-Acting Ligands by Ligand-Phospholipid Conjugation

通过配体-磷脂缀合开发长效配体的多功能策略

• 批准号: 16K15136
• 负责人: SHUTO Satoshi
• 金额: $ 2.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15136/
• 关键词: レジデンスタイム; リン脂質; トルテロジン; ムスカリン受容体

项目成果

Ligand-Phospholipid Conjugation: a Versatile Strategy for Developing Long-Acting Ligands that Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand

配体-磷脂缀合：通过限制配体的亚细胞定位来开发与膜蛋白结合的长效配体的多功能策略

• 发表时间: 2018
• 期刊: J. Med. Chem
• 作者: S. Kawamura;Y. Ito;T. Hirokawa;E. Hikiyama;S. Yamada;S. Shuto
• 通讯作者: S. Shuto

Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination

使用新型荧光配体和配体结合域组合对肌醇 1,4,5-三磷酸进行高灵敏度测量

• DOI: 10.1002/cbic.201600096
• 发表时间: 2016
• 期刊: ChemBioChem
• 影响因子: 3.2
• 作者: Oura;T.; Murata;K.; Morita;T.; Nezu;A.; Arisawa;M.; Shuto;S.; Tanimura;A.
• 通讯作者: A.

Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger

4α-叠氮乙基-环状 ADP-碳环-核糖的设计、合成和鉴定，作为环状 ADP-核糖（Ca2+ 动员第二信使）的高效类似物

• DOI: 10.1021/acs.jmedchem.6b00437
• 发表时间: 2016
• 期刊: J. Med. Chem.
• 影响因子: 7.3
• 作者: Sato;T.; Watanabe;M.; Tsuzuki;T.; Takano;S.; Murayama;T.; Sakurai;T.; Kameda;T.; Arisawa;M.; Fukuda;H.; Shuto;S.
• 通讯作者: S.

Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents

• DOI: 10.1021/acs.orglett.6b02612
• 发表时间: 2016-12-16
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Fukuda, Hayato;Muromoto, Ryuta;Shuto, Satoshi
• 通讯作者: Shuto, Satoshi