Useful β-turn mimetics having three-dimensional diversity

设计了面向立体化学多样性的b-转角模拟物，发展了高效、立体选择性的合成方法。将该模拟物应用于黑素皮质素受体配体的开发，我们发现了一种高效的非肽类先导化合物。因此，面向立体化学多样性的b-转弯模拟物被证明在开发非肽先导方面是有用的，特别是在缺乏配体的结合构象和受体的结构数据或缺乏文献记载的情况下。

The stereochemical diversity-oriented b-turn mimetics were designed and efficient and stereoselective synthetic method of them have been developed. Applying the mimetics to the development of melanocortin receptor ligands, we discovered a highly potent non-peptidic lead. Thus, the stereochemical diversity-oriented b-turn mimetics were shown to be useful in developing a non-peptidic lead, especially in cases where the binding conformation of the ligand and the structural data of the receptors are lacking or are poorly documented.