Endothelial autophagy deficiency induces interleukin 6-dependent endothelial mesenchymal transition and organ fibrosis

内皮自噬缺陷诱导白细胞介素6依赖性内皮间质转化和器官纤维化

• 批准号: 16K15472
• 负责人: KOYA Daisuke
• 金额: $ 2.25万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15472/
• 关键词: 内皮細胞; オートファジー; 線維化; 高脂肪食負荷; 腎臓; 心臓; 内皮間葉化; IL-6; 内皮・間葉化; 腎線維化; 心線維化; 膵島; 内皮; 内皮間葉転化; 上皮間葉転化; 糖尿病; 内皮・間葉転化; 血管内皮細胞

项目成果

Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II

• DOI: 10.1161/hypertensionaha.117.09247
• 发表时间: 2017
• 期刊: Hypertension
• 影响因子: 8.3
• 作者: Norikazu Ueki;K. Kanasaki;M. Kanasaki;S. Takeda;D. Koya

The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans.

• DOI: 10.3390/nu9101142
• 发表时间: 2017-10-18
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Kitada M;Ogura Y;Maruki-Uchida H;Sai M;Suzuki T;Kanasaki K;Hara Y;Seto H;Kuroshima Y;Monno I;Koya D
• 通讯作者: Koya D

PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity

• DOI: 10.2337/db16-0881
• 发表时间: 2017-04-01
• 期刊: DIABETES
• 影响因子: 7.7
• 作者: Onogi, Yasuhiro;Wada, Tsutomu;Sasaoka, Toshiyasu
• 通讯作者: Sasaoka, Toshiyasu

AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.

• DOI: 10.3390/ijms19103076
• 发表时间: 2018-10-09
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Kumagai A;Itakura A;Koya D;Kanasaki K
• 通讯作者: Kanasaki K

The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.

• DOI: 10.18632/aging.101068
• 发表时间: 2016-10-15
• 期刊: Aging
• 作者: Kitada M;Ogura Y;Koya D
• 通讯作者: Koya D