New therapeutic strategy for diabetic nephropathy

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Here, we hypothesized that mitochondria dysfunction due to aging-and diabetes-induced sirtuin 1(SIRT1) down regulation could result in renal inflammation, increased oxidative stress, and finally renal pathologies. Firstly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the aging kidneys, resulting in the amelioration of renal injuries. Secondly, resveratrol(RSV) ameliorates renal injury and enhanced mitochondrial biogenesis with Mn-SOD dysfunction in the kidney of db/db mice, through improvement of oxidative stress via normalization of Mn-SOD function and glucose-lipid metabolism via AMPK/SIRT1-independent pathway. Thirdly, calorie restriction exerts anti-inflammatory effects and improves the dysregulation of autophagy through the restoration of SIRT1 in the kidneys of WFRs, resulting in the amelioration of renal injuries in type 2 diabetes.