Biological functions of male mice songs平成 25年 4月 25 日現在

雄性小鼠鸣叫的生物学功能 截至2013年4月25日

• 批准号: 23657062
• 负责人: KIKUSUI Takefumi
• 金额: $ 2.5万
• 依托单位: Azabu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23657062/
• 关键词: 行動生理; 求愛歌; フェロモン; 性行動; 繁殖効率; 嗜好性; マウス; GnRH; アンドロゲン

In this study, we demonstrated that 1) we used the two-choice test to determine the song preference of female mice by assessing the time engaged in searching behavior towards played-back songs. We determined that female mice can discriminate among male song characteristics and that females innately prefer songs from strains that are different from their parents. 2) this preference was reversed by cross-fostering and disappeared by fatherless rearing conditions, indicating that the preference was learned or could be modified by social experience with their fathers. 3) this preference was controlled under estrogens. 4) there was a positive correlation between emission number of songs of males and giving birth of females in pairs. 5) the preference identified in this study was observed when females were exposed to soiled male bedding or the male mouse pheromone ESP1, which we previously reported enhanced female sexual receptivity (Nature 2010). This result suggests that cross-modal information processing from both acoustic and olfactory signals may influence mate preference in mice.

在这项研究中，我们证明了：1）我们使用两个选择测试，以确定歌曲偏好的雌性小鼠通过评估的时间从事搜索行为对播放的歌曲。我们确定雌性小鼠可以区分雄性歌曲特征，并且雌性小鼠天生更喜欢与其父母不同的歌曲。2)这种偏好被交叉抚养逆转，在无父抚养条件下消失，表明这种偏好是后天习得的，或者可以通过与父亲的社会经历来改变。3)这种偏好在雌激素下得到控制。4)雄鸟鸣唱次数与雌鸟成对分娩次数呈正相关。5)当雌性暴露于弄脏的雄性寝具或雄性小鼠信息素ESP 1时，观察到本研究中鉴定的偏好，我们先前报道了增强的雌性性感受性（Nature 2010）。这一结果表明，来自听觉和嗅觉信号的跨通道信息处理可能会影响小鼠的择偶偏好。

项目成果

雌マウスの雄マウス求愛歌に対する嗜好性は幼少期に獲得される

雌性小鼠对雄性小鼠求爱歌曲的偏好是在童年时期获得的。

• 发表时间: 2011
• 作者: 浅場明莉;岡部祥太;永澤美保;茂木一孝;菊水健史
• 通讯作者: 菊水健史

伴侶動物学研究室

伴侣动物学实验室

メスマウスのオス求愛歌嗜好性と繁殖機能に関する研究

雄性求爱歌曲偏好与雌性小鼠生殖功能的研究

• 发表时间: 2011
• 作者: 浅場明莉;永澤美保;茂木一孝;菊水健史
• 通讯作者: 菊水健史

Social cues and neural mechanisms in mother-pup interactions

母仔互动中的社会线索和神经机制

• 发表时间: 2011
• 作者: 浅場明莉;永澤美保;茂木一孝;菊水健史;Takefumi Kikusui
• 通讯作者: Takefumi Kikusui

Cross fostering experiments suggest that mice songs are innate.

• DOI: 10.1371/journal.pone.0017721
• 发表时间: 2011-03-09
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kikusui T;Nakanishi K;Nakagawa R;Nagasawa M;Mogi K;Okanoya K
• 通讯作者: Okanoya K