Development of a methodology for the selective stimulation of new born granule cells in mammalian hippocampus
Development of a methodology for the selective stimulation of new born granule cells in mammalian hippocampus
批准号:
23657058
负责人:
FURUKAWA Yasuo
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
利用无脊椎动物的肽门控Na+通道(FaNaC),我们试图建立一种刺激海马齿状回新生神经元的方法。制备了FaNaC的几种突变通道,发现其中两种对FMRFamide更敏感,并且与野生型通道相比显示出更少的脱敏。我们现在正试图在齿状颗粒神经元中表达这些突变通道。
英文摘要
By using an invertebrate peptide-gated Na+channel (FaNaC), we tried to establish a methodology to stimulate new neurons in the dentate gyrus of hippocampus. Several mutant channels of FaNaC were made, and two of them were found to be more sensitive to FMRFamide and show less desensitization compared to the wild-type channel. We are now trying to express these mutant channels in the dentate granule neurons.
期刊论文(20)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Electrostatic charge at position 552 of FMRFamide-gated Na+ channel affects channel activation and rectification
FMRFamide 门控 Na 通道 552 位的静电荷影响通道激活和整流
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Y. Kodani, Y. Furukawa]
通讯作者:
Y. Furukawa
An aspartate residue in the second transmembrane domain is critical for the function of FMRFamide-gated Na^+ channel
第二跨膜结构域中的天冬氨酸残基对于 FMRFamide 门控 Na^ 通道的功能至关重要
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[古川康雄, 小谷侑]
通讯作者:
小谷侑
DOI:
10.1016/j.peptides.2012.08.025
发表时间:
2012-12
期刊:
Peptides
影响因子:
3
作者:
[F. Morishita;Y. Furukawa;O. Matsushima]
通讯作者:
F. Morishita;Y. Furukawa;O. Matsushima
Systemic angiotensin II and its type I receptor are essential for running-enhanced neurogenesis in adult rat hippocampus
全身血管紧张素 II 及其 I 型受体对于成年大鼠海马跑步增强神经发生至关重要
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[T. Mukuda, Y. Koyama, S. Hamasaki, Y. Furukawa]
通讯作者:
Y. Furukawa
運動による海馬神経新生の促進作用に対する血中アンギテンシン II の関与
血液血管紧张素II参与运动促进海马神经发生
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小山友香, 濱崎佐和子, 椋田崇生, 古川康雄]
通讯作者:
古川康雄
共 12 条
A study on the molecular mechanisms of the functions of a peptide-gated Na^+ channel
-
批准号:20570071
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2008
-
负责人:FURUKAWA Yasuo
-
依托单位:
A study on the structure-function relationship and the physiological function of the peptide-gated sodium channel
-
批准号:18570071
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.57万
-
财政年份:2006
-
负责人:FURUKAWA Yasuo
-
依托单位:
A study on the inactivation of voltage-gated potassium channels.
-
批准号:09640810
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:FURUKAWA Yasuo
-
依托单位:
海外基金