System evolution in chorate morphogenesis in view of gene evolution of noncoding exons

为了了解脊索动物非编码外显子1的出现和退化如何参与脊索动物的形态进化，我们利用几个脊索动物物种对睾丸形成相关基因Dmrt1进行了分析。结果表明，DMRT1‘S非编码外显子1可能是在脊椎动物进化过程中产生的，它可能给了该基因两种类型的启动子，导致了表达模式的差异。然而，在羊膜动物进化过程中，由于DMRT1功能的改变，肠道的形成和维持可能已经退化。

To understand how emergence and degeneration of noncoding exon 1 is involved in morphological evolution in chordates, a testis formation-related gene Dmrt1was analyzed using several chordate species. The results indicated that Dmrt1’s noncoding exon 1 might have emerged during vertebrate evolution, which could give the gene two types of promoters, contributing to divergence of expression patterns. However, it might have degenerated because of changes of DMRT1 functions intestis formation and maintenance during amniote evolution.