System evolution in chorate morphogenesis in view of gene evolution of noncoding exons

为了了解非编码外显子1的出现和退化是如何参与脊索动物的形态进化的，睾丸形成相关基因Dmrt 1进行了分析，使用几个脊索动物物种。结果表明，Dmrt 1的非编码外显子1可能是在脊椎动物进化过程中出现的，这可能使该基因具有两种类型的启动子，从而导致表达模式的差异。然而，由于DMRT 1在动物进化过程中的功能改变，肠道的形成和维持，可能使其退化。

To understand how emergence and degeneration of noncoding exon 1 is involved in morphological evolution in chordates, a testis formation-related gene Dmrt1was analyzed using several chordate species. The results indicated that Dmrt1’s noncoding exon 1 might have emerged during vertebrate evolution, which could give the gene two types of promoters, contributing to divergence of expression patterns. However, it might have degenerated because of changes of DMRT1 functions intestis formation and maintenance during amniote evolution.