System evolution in chorate morphogenesis in view of gene evolution of noncoding exons

为了了解非编码外显子1的出现和退化如何参与脊索动物的形态进化，我们使用几种脊索动物来分析睾丸形成相关基因dmrt1。结果表明，Dmrt1的非编码外显子1可能是在脊椎动物进化过程中出现的，这可能使该基因具有两种类型的启动子，导致了表达模式的差异。然而，它可能是由于羊膜进化过程中DMRT1功能、形成和维持的改变而退化的。

To understand how emergence and degeneration of noncoding exon 1 is involved in morphological evolution in chordates, a testis formation-related gene Dmrt1was analyzed using several chordate species. The results indicated that Dmrt1’s noncoding exon 1 might have emerged during vertebrate evolution, which could give the gene two types of promoters, contributing to divergence of expression patterns. However, it might have degenerated because of changes of DMRT1 functions intestis formation and maintenance during amniote evolution.