Evolution of sex-determining systems in vertebrates
Evolution of sex-determining systems in vertebrates
批准号:
20370093
负责人:
ITO Michihiko
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
本文对脊椎动物进化过程中的性别决定系统进行了分析和讨论,提出了在非哺乳类脊椎动物中可能存在由DMRT 1驱动的基本雄性性别决定系统,并在哺乳动物进化过程中转变为SRY-SOX 9雄性性别决定系统的假说。我们还提出了一个性别决定基因与性染色体的协同进化模型,其中未分化的性染色体很容易允许性别决定基因被另一个新的性别决定基因取代,而特化的性染色体则被特定的性别决定基因所限制。
英文摘要
We analyzed and discussed sex-determining systems during vertebrate evolution, proposing a hypothesis that there might be a basic male sex-determining system driven by DMRT1 in non-mammalian vertebrates and that it might be changed into a SRY-SOX9 male sex-determining system during mammalian evolution. We also proposed a coevolution model of sex-determining genes and sex chromosomes, in which undifferentiated sex chromosomes easily allow replacement of a sex-determining gene with another new one, while specialized sex chromosomes are restricted a particular sex-determining gene.
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A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system
W连锁基因DM-W可以作为具有ZZ/ZW型性别决定系统的非洲爪蟾的性别(卵巢)决定基因诱导雌性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[應〓文, 北原和樹, 飯島玲生, 小野直亮, 古澤力, 鈴木真吾, 岸本利彦, 四方哲也, Michihiko Ito]
通讯作者:
Michihiko Ito
A W-linked gene DM-W could determine female development as a sex (ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system.
W 连锁基因 DM-W 可以作为非洲爪蟾性别(卵巢)决定基因来决定雌性发育:对 ZZ/ZW 型性别决定系统的影响。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ito, M., Yoshimoto, S., Takamatsu, N.]
通讯作者:
N.
A W-linked gene DM-W could induce female sex as a sex(ovary)-determining gene in Xenopus laevis that has the ZZ/ZW-type sex-determining system.
W连锁基因DM-W可以作为具有ZZ/ZW型性别决定系统的非洲爪蟾的性别(卵巢)决定基因诱导雌性。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ito, M., Yoshimoto, S., Takamatsu, N.]
通讯作者:
N.
A W-linked DM-W is a likely sex (ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex-determining system.
W 连锁的 DM-W 是非洲爪蟾中可能的性别(卵巢)决定基因:对 ZZ/ZW 型性别决定系统的影响。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Bei-Wen Ying, Saburo Tsuru, Yuki Matsumoto, Yoshihiro Shimizu, Yoichiro Ito, Tetsuya Yomo, Michihiko Ito]
通讯作者:
Michihiko Ito
A W-linked gene DM-W could determine female development as a sex(ovary)-determining gene in Xenopus laevis : Implications for the ZZ/ZW-type sex determining system.
W 连锁基因 DM-W 可以作为非洲爪蟾性别(卵巢)决定基因来决定雌性发育:对 ZZ/ZW 型性别决定系统的影响。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[應〓文, 北原和樹, 飯島玲生, 小野直亮, 古澤力, 鈴木真吾, 岸本利彦, 四方哲也, Michihiko Ito, 山岸明彦, Michihiko Ito]
通讯作者:
Michihiko Ito
共 11 条
System evolution in chorate morphogenesis in view of gene evolution of noncoding exons
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批准号:23657159
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2011
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负责人:ITO Michihiko
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依托单位:
Molecular Evolution of Sex-determining Genes during Vertebrate Evolution
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批准号:18570218
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.63万
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财政年份:2006
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负责人:ITO Michihiko
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依托单位:
Signal transduction by MAPK cascade scaffold proteins
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批准号:13680723
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2001
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负责人:ITO Michihiko
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依托单位:
海外基金